局部进展期胃癌术后同步放化疗的疗效分析

目的:研究局部进展期胃癌根治术后同步放化疗的疗效、不良反应及生活质量.方法:将68例胃癌术后病人随机分为同步放化疗组和单纯化疗组,各34例,同步放化疗组采用卡培他滨同步放化疗,单纯化疗组行奥沙利铂+卡培他滨化疗.比较2组1、2、3年无进展生存率、总生存率、不良反应及生活质量差异.结果:同步放化疗组1、2、3年无进展生存率高于单纯化疗组(P<0.05);而1、2、3年总生存率,2级及以上胃肠道反应、血液系统毒性、外周神经毒性和1级及以上手足综合征的发生率2组差异均无统计学意义(P>0.05).2组生活质量评分差异亦无统计学意义(P>0.05).结论:胃癌术后同步放化疗较单纯术后化疗提高了1、2、3 年无进展生存率,不良反应能耐受,未降低病人生活质量.

The curative effect analysis of the concurrent chemoradiotherapy in locally advanced gastric cancer after operation

Objective:To study the efficacy,adverse reaction and quality of life of the locally advanced gastric cancer patients treated with concurrent chemoradiotherapy.Methods:Sixty-eight postoperative patients with gastric cancer were randomly divided into the concurrent chemoradiotherapy group and single chemotherapy group(34 cases each group).The concurrent chemoradiotherapy group was treated with capecitabine combined with the intensity-modulated radiotherapy,while the single chemotherapy group was treated with oxaliplatin combined with capecitabine.The 1,2 and 3-year progression-free survival rates,overall survival rates,adverse reaction and quality of life between two groups were compared.Results:The 1,2 and 3-year progression-free survival rates in concurrent chemoradiotherapy group were higher than those in single chemotherapy group(P<0.05).The differences of the 1,2 and 3-year overall survival rates,incidence of more than or equal to grade 2 gastrointestinal reactions,hematological toxicity,peripheral nerve toxicity,incidence of more than or equal to grade 1 hand-foot syndrome and quality of life between two groups were not statistically significant(P>0.05).Conclusions:Compared with the single chemotherapy,the postoperative concurrent chemoradiotherapy can improve the 1,2 and 3-year progression-free survival rates,the adverse reaction can be tolerated,and do not reduce the quality of life of the patients.