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雌孕激素序贯疗法预防宫腔镜下子宫纵隔电切术后宫腔粘连的价值探讨
引用本文:许秀霞,郭志坚,林彤,吴巧珠,吴淑卿. 雌孕激素序贯疗法预防宫腔镜下子宫纵隔电切术后宫腔粘连的价值探讨[J]. 蚌埠医学院学报, 2017, 42(2). DOI: 10.13898/j.cnki.issn.1000-2200.2017.02.014
作者姓名:许秀霞  郭志坚  林彤  吴巧珠  吴淑卿
作者单位:广东省汕头市中心医院 妇产科,515031;广东省汕头市中心医院 妇产科,515031;广东省汕头市中心医院 妇产科,515031;广东省汕头市中心医院 妇产科,515031;广东省汕头市中心医院 妇产科,515031
基金项目:广东省汕头市科技计划项目
摘    要:目的:观察宫腔镜下子宫纵隔电切术的疗效,评价术后应用雌孕激素序贯疗法预防宫腔粘连的价值.方法:选取子宫纵隔患者60例,随机分为对照组和观察组,各30例.2组患者均行腹腔镜监视下宫腔镜子宫纵隔电切术,对照组术后放置宫内节育器(金属圆环);观察组放置宫内节育器(金属圆环),并采用雌孕激素序贯人工周期疗法.所有患者于术后3个月行宫腔镜复查,比较2组宫腔粘连情况;继续随访至术后1年,比较2组患者妊娠及月经情况.结果:所有患者均顺利完成手术,无明显并发症发生.2组患者术后3个月宫腔粘连率差异无统计学意义(P>0.05);2组术后1年经期紊乱、经量增多及妊娠率差异亦均无统计学意义(P>0.05).结论:宫腔镜下子宫纵隔电切术安全有效,能有效提高患者妊娠率,但术后应用雌孕激素序贯疗法预防宫腔粘连未见明显价值.

关 键 词:子宫纵隔  子宫纵隔电切术  宫腔镜  雌孕激素序贯疗法  宫腔粘连

Effect of the sequential estrogen and progestogen therapy on preventing the intrauterine adhesion after hysteroscopic uterine septum resection
XU Xiu-xia,GUO Zhi-jian,LIN Tong,WU Qiao-zhu,WU Shu-qing. Effect of the sequential estrogen and progestogen therapy on preventing the intrauterine adhesion after hysteroscopic uterine septum resection[J]. Journal of Bengbu Medical College, 2017, 42(2). DOI: 10.13898/j.cnki.issn.1000-2200.2017.02.014
Authors:XU Xiu-xia  GUO Zhi-jian  LIN Tong  WU Qiao-zhu  WU Shu-qing
Abstract:Objective:To observe the effects of hysteroscopic uterine septum resection,and evaluate the value of sequential estrogen and progestogen therapy on preventing the postoperative intrauterine adhesion. Methods:Sixty patients with uterine mediastinum were randomly divided into the control group and observation group ( 30 cases each group ) . Two groups were treated with hysteroscopic uterine septum resection. The intrauterine device in two groups were placed after operation,and the observation groups were treated with sequential estrogen and progestogen artificial cycle therapy. All patients were reexamined using hysteroscopy after 3 months of operation, and the intrauterine adhesion between two groups were compared. All patients were followed up for 1 year, and the pregnancy and menstrual condition between two groups were compared. Results:All operations were successfully completed, and no obvious complication was found in two groups. The difference of the intrauterine adhesion after 3 months of operation between two groups was not statistically significant(P>0. 05). After 1 year of operation,the differences of the rates of menstrual disorder,profuse menstruation and pregnancy between two groups were not statistically significant(P>0. 05). Conclusions:The hysteroscopic uterine septum resection is safe and effective, which can effectively improve the pregnancy rate. The effect of sequential estrogen and progestogen therapy on preventing the postoperative intrauterine adhesion is not obvious.
Keywords:uterine septum  uterine septum resection  hysteroscopy  sequential estrogen and progestogen therapy  intrauterine adhesion
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