食管鳞癌组织中乳腺癌扩增基因1的表达及临床意义

目的:探讨乳腺癌扩增基因1(AIB1)在食管鳞癌组织中的表达及其临床意义.方法:用免疫组织化学法检测AIB1蛋白在60例食管鳞癌组织和30例癌旁正常食管黏膜组织中的表达,分析其与各临床病理因素之间的相关性.结果:60例食管鳞癌组织中AIB1蛋白的表达率为53.3%,30例癌旁正常黏膜组织中AIB1蛋白不表达或弱阳性表达,差异有统计学意义(P<0.01);食管鳞癌组织中 AIB1蛋白的表达在不同肿瘤分化程度、淋巴结转移及临床分期间差异均有统计学意义 (P<0.05~P<0.01),而在不同年龄、性别及浸润深度间表达差异均无统计学意义(P>0.05).结论:AIB1蛋白在食管鳞癌组织中异常高表达,表明其可能影响食管鳞癌发生发展及浸润转移的进程.

Expression of AIB1 protein in esophageal squamous cell carcinoma,and its clinical significance

Objective:To investigate the expression of amplified in breast cancer 1(AIB1) protein in esophageal squamous cell carcinoma,and its clinical significance.Methods:The expressions of AIB1 in esophageal squamous cell carcinoma tissue(60 samples) and normal esophageal mucosa tissue(30 samples) were detected using immunohistochemical technique,and the correlation between the AIB1 expression and clinicopathology was analyzed.Results:The positive rate of AIB1 in esophageal squamous cell carcinoma tissue was 53.3%,the AIB1 protein expression in normal esophageal mucosa was negative or weak positive,and the difference of the AIB1 expression between two kinds of tissues was statistically significant(P<0.01).The differences of the AIB1 expression in different differentiation,lymph node metastasis and clinical stages tumors were statistically significant(P<0.05 to P<0.01).The differences of the AIB1 expression in different ages and sexuality patients,and invasive depth tumor were not statistically significant(P>0.05).Conclusions:Abnormal high expression of AIB1 protein in esophageal squamous cell carcinoma may affect the occurrence,development,invasion and metastasis process of tumor.