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Reduced nocturnal morphine analgesia in mice following a geomagnetic disturbance |
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| Authors: | K. -P. Ossenkopp M. Kavaliers M. Hirst |
| Affiliation: | 1 Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2, Canada 2 Department of Zoology, University of Western Ontario, London, Ontario N6A 5C2, Canada 3 Department of Pharmacology and Toxicology, University of Western Ontario, London, Ontario N6A 5C2, Canada |
| Abstract: | Latency to respond to an aversive thermal stimulus and the degree of analgesia induced by morphine were examined in mice injected with either isotonic saline or morphine sulfate (10 mg/kg) during midscotophase of a 12:12 h LD cycle. When mean response latencies were compared to the degree of geomagnetic disturbance (Ap index) present on test days, it was found that during the geomagnetic storm on December 17th, 1982, a significant reduction (P<0.01) in response latency was evident in both saline- and morphine-treated mice. The reduction in response latencies was greater, and lasted longer in the morphine-treated animals. It is suggested that the pineal gland may mediate this biomagnetic effect. |
| Keywords: | geomagnetic disturbance pain thresholds morphine analgesia hot-plate test biomagnetic effect mice |
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