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哌甲酯及托莫西汀对注意缺陷多动障碍儿童HPA轴功能的影响
引用本文:陈燕惠,陈辉,刘艳艳,林桂秀,韦立新,洪艳玲. 哌甲酯及托莫西汀对注意缺陷多动障碍儿童HPA轴功能的影响[J]. 儿科药学杂志, 2011, 17(1): 20-23
作者姓名:陈燕惠  陈辉  刘艳艳  林桂秀  韦立新  洪艳玲
作者单位:福建医科大学附属协和医院;
基金项目:福建医科大学协和临床学院教授基金课题(JS07008)
摘    要:
目的:通过研究哌甲酯(MPH)及托莫西汀(ATX)治疗前后注意缺陷多动障碍(ADHD)儿童下丘脑-垂体-肾上腺(HPA)轴的功能状态,探讨HPA轴在ADHD中的作用.方法:采用前瞻、双盲、随机对照研究方法,根据美国<精神病诊断与统计手册>(第4版)(DSM-IV)ADHD诊断和分型标准确诊111例6~14岁ADHD男童...

关 键 词:注意缺陷多动障碍  皮质醇  哌甲酯  托莫西汀  儿童

The Influences of Methylphenidate and Tomoxetine on the Function of HPA in Children with ADHD
Chen Yanhui,Chen Hui,Liu Yanyan,Lin Guixiu,Wei Lixin,Hong Yanling. The Influences of Methylphenidate and Tomoxetine on the Function of HPA in Children with ADHD[J]. Journal of Pediatric Pharmacy, 2011, 17(1): 20-23
Authors:Chen Yanhui  Chen Hui  Liu Yanyan  Lin Guixiu  Wei Lixin  Hong Yanling
Affiliation:Chen Yanhui,Chen Hui,Liu Yanyan,Lin Guixiu,Wei Lixin,Hong Yanling(Union Hospital of Fujian Medical University,Fujian Fuzhou 350001,China)
Abstract:
Objective:To explore the relationship between hypothalamus-pituitary-adrenal(HPA) and ADHD.The function of HPA axis in children with ADHD has been investigated before and after the treatment of methylphenidate(MPH) and atomoxetine(ATX).Methods: The clinical study was a prospective,double-blind,randomized case-control trail.One hundred and eleven male children with ADHD between the ages of 6 to 14 years old were included in this study.The diagnosis of ADHD and its three subtypes were according to the handboo...
Keywords:Attention deficit hyperactivity disorder  Cortisol  Methylphenidate  Atomoxetine  Children  
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