| NLRP3炎症小体与糖尿病性心肌病研究进展 |
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| 引用本文： | 李雪莲,李智洋,李宾公,赖性君. NLRP3炎症小体与糖尿病性心肌病研究进展[J]. 中国药理学通报, 2019, 0(8): 1051-1054 |
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| 作者姓名： | 李雪莲 李智洋 李宾公 赖性君 |
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| 作者单位： | 1.南昌大学第一附属医院心内科;2.南京医科大学 |
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| 基金项目： | 国家自然科学基金资助项目(No 81860052,81460046) |
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| 摘 要： | 糖尿病的重要心血管并发症之一是糖尿病心肌病(diabetic cardiomyopathy,DCM)。代谢紊乱、线粒体损伤、心肌细胞凋亡和自噬都被证实参与了DCM的发生、发展。近年来研究证实,核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体可能与DCM的发生、发展密切相关,是DCM治疗的潜在靶点。该文总结了NLRP3炎性小体与DCM的研究进展,为未来治疗DCM提供新的方向。
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| 关 键 词： | NLRP3 糖尿病心肌病 自噬 氧化应激 NF-ΚB 活性氧 |
Research progress of NLRP3 inflammasome in diabetic cardiomyopathy |
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| LI Xue-lian,LI Zhi-yang,LI Bin-gong,LAI Xing-jun. Research progress of NLRP3 inflammasome in diabetic cardiomyopathy[J]. Chinese Pharmacological Bulletin, 2019, 0(8): 1051-1054 |
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| Authors: | LI Xue-lian LI Zhi-yang LI Bin-gong LAI Xing-jun |
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| Affiliation: | (Dept of Cardiology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Nanjing Medical University,Nanjing 211166,China) |
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| Abstract: | Diabetic cardiomyopathy(DCM) is one of the important cardiovascular complications of diabetes mellitus.Metabolic disorders,mitochondrial damage,cardiomyocyte apoptosis and autophagy are involved in the development of DCM.Recent research demonstrates that NLRP3 inflammasome plays a vital role in the pathogenesis of DCM,and has emerged as a potential target for the treatment of DCM.In this article,research progress in NLRP3 inflammasome and DCM has been reviewed,aiming to provide novel therapeutic idea for the treatment of DCM. |
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| Keywords: | NLRP3 DCM autophagy oxidative stress NF-κB reactive oxygen species |
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