| 锌指蛋白A20在过敏性哮喘中的研究进展 |
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| 引用本文： | 袁为远,包凯帆,贾志荣,王晓钰,郑劼,洪敏,江国荣.锌指蛋白A20在过敏性哮喘中的研究进展[J].中国药理学通报,2019(5):607-611. |
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| 作者姓名： | 袁为远 包凯帆 贾志荣 王晓钰 郑劼 洪敏 江国荣 |
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| 作者单位： | 1.南京中医药大学药学院科技部国家规范化中药药理实验室江苏省中药药效与安全性评价重点实验室;2.南京中医药大学附属苏州市中医医院苏州市吴门医派研究院;3.南京中医药大学医学与生命科学学院药理系 |
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| 基金项目： | 国家自然科学基金资助项目(No 81473395;81373549);江苏省自然科学基金资助项目(No BK20141466);江苏省儿童呼吸疾病(中医药)重点实验室资助项目(No JKLPRD201405);江苏高校优势学科建设工程资助项目 |
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| 摘 要： | 锌指蛋白A20(也称TNFAIP3)是一种可在多种炎症条件,如LPS、IL-1、TNF-α等刺激下,被激活的具有去泛素化和泛素化双重功能的胞质蛋白。目前,A20被认为是NF-κB的负调控因子,具有免疫调节作用。最新研究表明,A20参与了过敏性哮喘的发生和发展。因此,该文对A20的起源、结构、生物学功能及其在过敏性哮喘中的作用进行综述,以期为过敏性哮喘的治疗和预防提供新的方法和思路。
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| 关 键 词： | A20 NF-κB抑制因子 过敏性哮喘 炎症 免疫调节 过敏性疾病 |
Research progress of zinc finger protein A20 in allergic asthma |
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| YUAN Wei-yuan,BAO Kai-fan,JIA Zhi-rong,WANG Xiao-yu,ZHENG Jie,HONG Min,JIANG Guo-rong.Research progress of zinc finger protein A20 in allergic asthma[J].Chinese Pharmacological Bulletin,2019(5):607-611. |
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| Authors: | YUAN Wei-yuan BAO Kai-fan JIA Zhi-rong WANG Xiao-yu ZHENG Jie HONG Min JIANG Guo-rong |
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| Institution: | (College of Pharmacy,Nanjing University of Chinese Medicine,Jiangsu Key Lab for Pharmacology and Safety Evaluation ofChinese Materia Medica,Nanjing210023,China;Dept of Pharmacology,School of Medicine and Life Sciences,Nanjing University of Chinese Medicine,Nanjing210023,China;Suzhou Wu Men Yi Pai Research Institute,the AffiliatedSuzhou Hospital of TCM of Nanjing University of Chinese Medicine,Suzhou Jiangsu215003,China) |
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| Abstract: | A20 (also known as TNFAIP3) is a zinc finger protein with both ubiquitination and deubiquitination functions,which can be activated by a variety of inflammatory factors such as LPS,IL-1 and TNF-α.To date,A20 has been considered a negative regulator of NF-κB with immunomodulatory effects.And the latest researches have shown the involvement of A20 in the occurrence and development of various allergic diseases.This article reviews the origin,structure,and biological functions of A20 and its role in allergic asthma,through which new methods and ideas might be enlightened for the treatment and prevention of allergic asthma. |
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| Keywords: | A20 NF-κB inhibitor allergic asthma inflammation immune regulation allergic diseases |
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