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| 1-磷酸鞘氨醇及其信号通路在炎症相关性疾病中的作用 | |
| 引用本文： | 卜妍红,吴虹,孙明慧,张衡,戴学静,王言,占翔. 1-磷酸鞘氨醇及其信号通路在炎症相关性疾病中的作用[J]. 中国药理学通报, 2019, 0(8): 1041-1046 |
| 作者姓名： | 卜妍红 吴虹 孙明慧 张衡 戴学静 王言 占翔 |
| 作者单位： | 1.安徽中医药大学药学院新安医学教育部重点实验室中药复方安徽省重点实验室 |
| 基金项目： | 国家自然科学基金面上项目(No 81874360,81473400);安徽中医药大学探索性科研项目(No RD17100457) |
| 摘 要： | 1-磷酸鞘氨醇(sphingosine 1-phosphate,S1P)是细胞膜鞘磷脂在代谢过程中产生的一类重要的信号分子,S1P可被转运到细胞外,通过作用于S1P受体,激活一系列下游信号分子发挥作用,如Ras/Raf/ERK、PI3K/Akt等,也可作为第二信使直接作用于细胞内靶点,如HDAC、TRAF2。其介导的信号通路在很多生理和病理过程中发挥作用,如细胞增殖和迁移、炎性细胞因子浸润、血管生成、自身免疫等。该文分别从S1P的胞外及胞内两种作用方式,探讨S1P及其信号通路在炎症相关性疾病中的作用,综述S1P信号通路相关药物研究进展。 |
| 关 键 词： | 1-磷酸鞘氨醇 鞘氨醇激酶 G蛋白偶联受体 组蛋白去乙酰化酶 信号通路 炎症 |
Role of sphingosine-1-phosphate and its signaling pathway in inflammation-related diseases |
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| BU Yan-hong,WU Hong,SUN Ming-hui,ZHANG Heng,DAI Xue-jing,WANG Yan,ZHAN Xiang. Role of sphingosine-1-phosphate and its signaling pathway in inflammation-related diseases[J]. Chinese Pharmacological Bulletin, 2019, 0(8): 1041-1046 | |
| Authors: | BU Yan-hong WU Hong SUN Ming-hui ZHANG Heng DAI Xue-jing WANG Yan ZHAN Xiang |
| Affiliation: | (School of Pharmacy,Anhui University of Chinese Medicine,Key Lab of Xin′an Medicine,Ministry of Education,Anhui Province Key Lab of Chinese Medicinal Formula,Hefei 230012,China) |
| Abstract: | Sphingosine 1-phosphate(S1P) is an important signal molecule produced by the metabolism of cell membrane sphingomyelin.S1P can be transported to the extracellular domain,and plays a role in activating a series of downstream signals,such as Ras/Raf/ERK,PI3K/AKT,by acting on S1P receptors.It can also act as a second messenger directly on intracellular targets such as HDAC,TRAF2.Its mediated signaling pathway plays a role in many physiological and pathological processes such as cell proliferation and migration,inflammatory cytokine infiltration,angiogenesis and autoimmunity.This article explores the role of S1P and its signaling pathways in inflammation-related diseases from the extracellular and intracellular roles of S1P,and reviews the research progress of S1P signaling pathway related drugs. |
| Keywords: | sphingosine-1-phosphate sphingosine kinase G protein coupled receptors histone deacetylase signaling pathway inflammation |
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