| 蜂王浆类制剂SK初乳素R-1对小鼠免疫功能的影响 |
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| 引用本文： | 谭虎 钱之玉. 蜂王浆类制剂SK初乳素R-1对小鼠免疫功能的影响[J]. 中国临床药理学与治疗学, 2006, 11(6): 684-686 |
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| 作者姓名： | 谭虎 钱之玉 |
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| 作者单位： | 中国药科大学药理教研室,江苏南京210009 |
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| 摘 要： | 目的：研究蜂王浆类制剂SK初乳素R-1对正常小鼠非特异性免疫功能、体液免疫功能、功细胞免疫功能的影响。方法：以SK初乳素R-1连续灌胃给药15d，测定小鼠增强小鼠炭末廓清能力、小鼠血清溶血素抗体水平、血清IL-2含量、抗体生成细胞数、脾淋巴细胞增殖能力等。结果：SK初乳素R-1各剂量组能增强小鼠炭末廓清率和廓清指数，各剂量组均能明显升高小鼠血清溶血素抗体水平（P〈0．01），提高小鼠血清IL-2含量（P〈0．01），促进小鼠抗体细胞形成（P〈0．01），增强ConA诱导的脾淋巴细胞增殖能力（P〈0．01）。结论：蜂王浆类制剂SK初乳素R-1具有增强小鼠免疫功能的作用。
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| 关 键 词： | 蜂王浆 免疫 溶血素 溶血空斑 |
| 文章编号： | 1009-2501(2006)06-0684-03 |
| 收稿时间： | 2006-03-17 |
| 修稿时间： | 2006-04-28 |
Immunoloregulation effect of SK Royaljelly R-1 in mice |
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| TAN Hu, QIAN Zhi-yu. Immunoloregulation effect of SK Royaljelly R-1 in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(6): 684-686 |
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| Authors: | TAN Hu QIAN Zhi-yu |
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| Affiliation: | Pharmacological Teaching and Research Group of China Pharmaceutical University, Nanjing 210009, Jiangsu, China |
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| Abstract: | AIM: To investigate the effect of SK Royaljelly R-1(SKR) on the innate immunity,humoral immunity,cell immunity in mice.METHODS:Observe the effect of SKR on immunity function in mice,the phagocytotic rate and phagocytotic index,haemolysin in serum,plaque forming cell,and the proliferation of splenocyte following administration SKR for 15 days.RESULT: SK Royaljelly R-1 improved the formulation of serum haemolysin significantly(P<(0.01)),increased PFC and Il-2 production significantly(P<(0.01)),and stimulated the splenocyte proliferation stimulated by ConA of normal mice(P<(0.01)).CONCLUSIION: The results suggeste SKR could potentiate the immunological function of normal mice. |
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| Keywords: | IL-2 |
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