Enhanced Incorporation of 1-β-D-Arabinofuranosylcytosine by Pretreatment with Etoposide期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Enhanced Incorporation of 1-β-D-Arabinofuranosylcytosine by Pretreatment with Etoposide

Authors:	Kazuya Ooi Toshiki Ohkubo Hiroshi Kuwabara Masamune Higashigawa Hajime Kawasaki Hideshi Kakitoh Yoshiyuki Kagawa Shoji Inagaki Katsumi Sumida Minoru Sakurai

Affiliation:	^a Department of Pharmacy, Social Insurance Hazu Hospital 10-8 Hazuyama-cho Yokkaichi-City Mie-Ken 510, Japan^b Department of Pediatrics, Mie University School of Medicine 2-174, Edobashl Tsu-City, Mie-Ken, 514, Japan^c Department of Pharmacy, Mie University School of Medicine 2-174, Edobashi Tsu-City, Mie-Ken, 514, Japan

Abstract:	We examined the effects of timing of administration of etoposide on cytosine arab-inoside (ara-C) incorporation into DNA in L1210 ascites tumor. At 1 hr after injection of ara-C, 3-hr and 6-hr pretreatments with 15 mg/kg of etoposide increased ara-C incorporation to more than 200% as compared to that of ara-C given alone. Simultaneous administration of etoposide, however, decreased ara-C incorporation to 33% of that of ara-C alone. These results might explain the previously reported sequence dependency of the antitumor effect of etoposide and ara-C.

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