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Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population |
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| Authors: | Ying Zeng Qing-Min Sun Nan-Nan Liu Guang-Hui Dong Jie Chen Li Yang and Bin Wang |
| Institution: | Ying Zeng, Nan-Nan Liu, Guang-Hui Dong, Jie Chen, Bin Wang, Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China;Qing-Min Sun, The Affiliated Wuxi Hospital for Maternal and Child Health Care of Nanjing Medical University, Wuxi 214002, Jiangsu Province, China;Li Yang, Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China |
| Abstract: | AIM:To investigate the association between pre-miR- 146a C/G polymorphism and gastric cancer risk. METHODS:We performed a hospital-based,case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals(304 gastric cancer patients and 304 age and sex matched cancer-free controls).RESULTS:The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups(P=0.037).Compared with CC genotype carriers,s... |
| Keywords: | Pre-miR-146a miR-146a Gastric cancer Polymorphism Genotype |
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