首页 | 本学科首页   官方微博 | 高级检索  
     

测定二盐酸盐类药物含量的线性滴定法
引用本文:冯新邦,汪葆浚,樊行雪. 测定二盐酸盐类药物含量的线性滴定法[J]. 药学学报, 1987, 22(11): 854-857
作者姓名:冯新邦  汪葆浚  樊行雪
作者单位:华东化工学院化学系 上海(冯新邦,汪葆浚),华东化工学院化学系 上海(樊行雪)
摘    要:
本文提出了一种测定二元有机碱二盐酸盐类药物含量的直线图解法,以取代传统的非水滴定法。实验以电位滴定为分析手段,滴定剂以分步等体积加入。等当点的确定同样也可采用线性回归法,数据处理仅采用一种TI-59型可编程序计算器便可完成。本文还就测定的结果是药物的生理活性部分含量,而不是盐酸酸根部分含量作了进一步的讨论。

关 键 词:线性滴定法  二元共轭酸  乙胺丁醇  培他司丁  哌仑西平  维生素B6
收稿时间:1986-10-20

DETERMINATION OF DIHYDROCHLORIDES OF DRUGS BY LINEAR TITRATION METHOD
FENG Xin-Bang,WANG Bao-Jun and FAN Xing-Xue. DETERMINATION OF DIHYDROCHLORIDES OF DRUGS BY LINEAR TITRATION METHOD[J]. Acta pharmaceutica Sinica, 1987, 22(11): 854-857
Authors:FENG Xin-Bang  WANG Bao-Jun  FAN Xing-Xue
Abstract:
A linear graphic method for the determination of the equivalence points of dihydrochlorides of drugs is presented in order to replace the traditional non-aqueous titration in pharmaceutical analysis. The titration is carried out potentiometrically. Equal volumes of the titrant are added stepwisely. The detection of end points of the titration by means of linear regression analysis is also recommended. The titration data can be treated by a programmable pocket calculator such as TI-59, and more satisfactory results are obtained than those when the salts are simply treated as a monohydrochloride. It is discussed further-more that the result from the method represents the part having the physiological activity of the drug, not the part of the hydrochloric acid redical.
Keywords:Linear titration method  Diprotic conjugate acid  Ethambutole  Betahistine  Pirenzepine  Pyridoxine
本文献已被 CNKI 等数据库收录!
点击此处可从《药学学报》浏览原始摘要信息
点击此处可从《药学学报》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号