| 垂体腺瘤p16基因的单链构象多态性分析 |
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| 引用本文： | 魏新亭,罗世祺. 垂体腺瘤p16基因的单链构象多态性分析[J]. 中国实用神经疾病杂志, 2001, 4(3): 3-4 |
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| 作者姓名： | 魏新亭 罗世祺 |
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| 作者单位： | 河南医科大学第一附属医院神经外科,郑州,450052;北京天坛医院神经外科,北京,100050 |
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| 摘 要： | 目的：筛选垂体腺瘤中ｐ１６基因的突变。方法：对无ｐ１６基因纯合性的肿瘤及其血标本进行单链构象多态性分析。结果：３０例标本中未见ｐ１６基因第一和第一外显子迁移率改变。结论：垂体腺瘤ｐ１６基因的表达缺失与基因突变无关。
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| 关 键 词： | 垂体腺瘤 p16基因 突变 |
| 修稿时间： | 2001-02-13 |
Single-strand conformation polymorphism analysis of p16 in pituitary adenomas |
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| Wei Xinting,luo shiqi. Single-strand conformation polymorphism analysis of p16 in pituitary adenomas[J]. Chinese Journal of Practical Neruous Diseases, 2001, 4(3): 3-4 |
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| Authors: | Wei Xinting luo shiqi |
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| Affiliation: | Wei Xinting,luo shiqi . Department of Neurosurgery,the first affiliated hospital of Henan Medical University,Zhengzhou 450052 |
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| Abstract: | Objective:: To screen the mutations of p16 gene in pituitary adenomas.Methods: Single-strand conformation polymorphism(SS- CP) techique was used to screen the mutations in exonl and 2 of p16 gene in pituitary adenomas which was not detected pl6 gene homozygous deletion by southern blot. Results: SSCP analyses for mutations in exon 1 and 2 of pl6 was performed in 30 normal-tumor DNA pairs and no mobility shift was detected in any of these samples. Conclusion: The loss of protein expression of p16 gene in pituitary adenomas was not related to the mutation of p16. |
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| Keywords: | Pituitary adenomas p16 gene Mutation |
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