Age-related difference in nociceptive behavior between SAMP6 and SAMR1 strains |
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Authors: | Kimie Niimi Eiki Takahashi Chitoshi Itakura |
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Institution: | 1. Brain Science and Life Technology Research Foundation, 1-28-12 Narimasu, Itabashi, Tokyo 175-0094, Japan;2. RIKEN Brain Science Institute, Research Resources Center, Hirosawa 2-1, Wako, Saitama 351-0198, Japan |
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Abstract: | Senescence accelerated prone mouse 6 (SAMP6) mice have been known to be a model for accelerated aging. Compared with the normal control senescence accelerated resistant mouse 1 (SAMR1) mice, although the SAMP6 mice have normal bone mass at 4 months, they exhibit a significantly lower bone mass at 8 months. It was recently reported that SAMP6 has memory deficit at 4 months of age, indicating that the change of nervous function might be already detected at 4 months of age. To assess whether SAMP6 mice exhibit an age-related abnormality of nociceptive transmission, we examined a battery of tests using the von Frey test for mechanically induced response, the hot plate test for thermally induced response, and the formalin paw test for chemically induced response. SAMP6 and SAMR1 showed similar response patterns in the von Frey test and the hot plate test. In the formalin paw test, 1-month-old SAMP6 and SAMR1 had similar responses, while 4-month-old SAMP6 exhibited attenuated phase 2 response, but normal phase 1 response. These findings indicate that onset of age-related phenotypes in SAMP6 differs in different tissues. SAMP6 could be useful to delineate the involvement of age-related nociceptive mechanisms. |
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Keywords: | von Frey test Hot plate test Formalin paw test SAMR1 SAMP6 |
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