他汀类药物对缺血性脑卒中的预防作用

他汀类药物具有竞争性抑制细胞内胆固醇合成早期过程中限速酶的活性,继而上调细胞表面LDL受体,加速血浆LDL的分解代谢,此外还可抑制极低密度脂蛋白的合成。因此,他汀类药物能显著降低TC、LDL-C和载脂蛋白B,也降低TG水平和轻度升高HDL-C。他汀类药物还可能具有抗炎、保护血管内皮功能等作用。临床试验显示,低密度脂蛋白胆固醇水平降低10%,脑卒中的发病率降低15.6%。研究表明,无论是脑卒中的二级预防还是心脏事件的二级预防,他汀类药物的治疗都是必要的,强化他汀类药物治疗是这一高危或极高危人群预防事件再发的关键治疗措施之一。

Preventive Effect of Statins on Cerebral Arterial Thrombosis

The statins can competitively restrict the activity of an enzyme which exist in the early stage of the compound of cholesterin in the cell,then it can upregulate the quantity of LDL receptor,accelerate the atabolism of LDL,beside that,it can also restrict the compound of very low-density lipoproteins.So the stains can obviously descend the TC,LDL-C,apoB and TG level,besides the effct that can slightly ascend the HDL-C level.The statins also have a function of anti-inflammatory,and protecting the vascular en...