乳腺实性乳头状癌中Ki-67的表达变化及其临床意义

目的 实性乳头状癌(SPC)是一种少见的特殊类型乳腺癌,占所有乳腺癌的1.3％,病理组织学有其独特特点.本研究探讨SPC临床病理特征及免疫表型,从而进一步了解这种少见类型的肿瘤.方法 收集广东省妇幼保健院2014-2019年诊断的49例SPC患者,回顾性分析其临床病理特征及免疫表型.结果 本组患者的中位数年龄为58岁(...

Change of Ki-67 expression in solid papillary carcinoma and its clinical significance

Objectives Solid papillary carcinoma(SPC)is a rare subset of breast carcinoma accounting for 1.3%of all patients with breast cancer.It has distinctive histological pattern.Here,we analyzed the clinicopathologic characteristics and immunophenotype of SPC to improve our understanding more about this uncommon tumour.Methods A total of 49 patients with SPC of the breast from the Guangdong Women and Children Hospital between 2014 and 2019 were enrolled in this study.Retrospective analysis of the clinicopathologic characteristics and immunophenotype was performed.Results Median age for all patients was 58 years(range 20-78 years).Among these cases,21 cases were diagnosed as SPC in situ and 27 cases were confirmed as SPC with invasion.The sentinel lymph node biopsy(SLNB)was performed in 35(71.4%)cases.Only one of them was with isolated tumour cells and no metastasis was found in other cases.Immunohistochemical staining was strongly and diffusely positive for ER and negative for HER-2 in all of the cases.48(98%)cases were positive for PR.Chromogranin A and/or synaptophysin were positive in 48 cases.The proliferation index of Ki-67 varied,ranging from 1%to 80%.Interestingly,Ki-67 expression in young patients(<58 years)was significantly higher than the old patients(≥58 years,P=0.001).However,no differences were observed between SPC in situ and SPC with invasion for Ki-67 expression(P=0.305).Conclusion SPC represents a distinct entity of breast carcinoma.It affects primarily elderly women,and it also can affect younger patients.It has distinctive histological pattern and is frequently positive for hormone receptor and neuroendocrine markers.The expression of Ki-67 is associated with the age of patients.Ki-67 index is higher in younger women than that in elderly ones.The prognostic value of high exprssion of Ki-67 in younger women with SPC needs further research.