上皮样炎性肌纤维母细胞肉瘤1例临床病理观察

目的 分析上皮样炎性肌纤维母细胞肉瘤(EIMS)的临床及病理特征,旨在提高对本病的认识及鉴别.方法 对1例EIMS进行免疫组化染色,荧光原位杂交检测ALK基因重排,观察其病理特点并复习文献.结果 患者女,56岁,腹痛2月余.肿物位于肠系膜,直径约15 cm,切面黏液样外观.镜下见肿瘤富于黏液背景,瘤细胞呈弥漫或团块状分...

Epithelioid inflammatory myofibroblastic sarcoma: a clinicopathologic analysis of one case

Objective To present a case report of epithelioid inflammatory myofibroblastic sarcoma(EIMS),aiming to enhance the understanding of its clinicopathological characteristics.Methods Immunohistochemistry was performed on a case of EIMS and FISH was employed to detect ALK fusion.Results A 56-year-old woman suffered stomachache for about 2 months.A mass was discovered in her abdominal cavity,which was approximately 15 cm in diameter and appeared with mucus-like cutting surface.Microscopic evaluation revealed the distribution of tumors cells into myxoid stroma,which were epitheloid,round,polygonal,short-spindle with abundant cytoplasm,vesicular nuclei,prominent nucleoli and a lot of mitosis.In addition,numerous inflammatory cells were observed in background that was predominated by neutrophilic cells.ALK was located on nuclear membrane by immunostaining with ALK(5 A4)and ALK(1 A4),and the gene fusion of ALK was identified by FISH.Moreover,tumor cells showed positive staining against vimentin,desmin,D2-40,WT-1 and CD99.The patient suffered recurrence two months later and survived for about five months.Conclusion EIMS is a soft tissue tumor with high malignancy,and its diagnosis depends on morphological changes and immunostaining.