神经钙黏蛋白在宫颈癌组织中的表达及临床意义

目的探讨神经钙黏蛋白在宫颈癌中的表达及其临床意义。方法随机选取2017年8月-2019年8月浙江省肿瘤医院全子宫切除术宫颈标本存档蜡块150例,分为宫颈鳞癌组76例、宫颈上皮内瘤变组50例和正常宫颈组织组24例,统计分析3组患者的N-cad、N-cadherin、HIF-1α、p53、p63表达情况,并分析宫颈鳞癌组患者的临床病理特征与N-cad表达的差异。结果宫颈鳞癌组患者的N-cad、N-cadherin、HIF-1α、p53表达阳性率均显著高于宫颈上皮内瘤变组、正常宫颈组织组,p63表达阳性率显著低于宫颈上皮内瘤变组、正常宫颈组织组,差异均有统计学意义(P<0.05)。宫颈上皮内瘤变组患者的N-cad、N-cadherin、HIF-1α、p53表达阳性率均显著高于正常宫颈组织组,p63表达阳性率显著低于正常宫颈组织组,差异均有统计学意义(P<0.05)。宫颈鳞癌组临床分期Ⅱ期患者的N-cad表达阳性率显著高于Ⅰ期患者,组织学分级G2-G3级患者的N-cad表达阳性率显著高于G1级患者,差异均有统计学意义(P<0.05);但不同年龄、淋巴结转移患者的N-cad表达阳性率之间的差异均无统计学意义(P>0.05)。结论神经钙黏蛋白在宫颈癌中的表达升高,能够将一种新的潜在靶分子提供给宫颈癌的治疗。

Expression of neural cadherin in cervical cancer tissue and the clinical significance

Objective To explore the expression of neural cadherin( N-cad) in cervical cancer and the clinical significance. Methods From August 2017 to August 2019,150 paraffin-embedded cervical tissue samples after total hysterectomy in Zhejiang Cancer Hospital were randomly selected and divided into cervical squamous cell carcinoma group( 76 samples),cervical intraepithelial neoplasia group( 50 samples),and normal cervical tissue group( 24 samples). The expressions of N-cad,N-cadherin,HIF-1α,p53,and p63 in the three groups were analyzed statistically. The expressions of N-cad in patients of different clinicopathological characteristics in cervical squamous cell carcinoma group were analyzed. Results The positive expression rates of N-cad,N-cadherin,HIF-1α,and p53 in cervical squamous cell carcinoma group were statistically significantly higher than those in cervical intraepithelial neoplasia group and normal cervical tissue group,the positive expression rate of p63 in cervical squamous cell carcinoma group were statistically significantly lower than those in cervical intraepithelial neoplasia group and normal cervical tissue group( P<0. 05). The positive expression rates of N-cad,N-cadherin,HIF-1α,and p53 in cervical intraepithelial neoplasia group were statistically significantly higher than those in normal cervical tissue group,the positive expression rate of p63 in cervical intraepithelial neoplasia group was statistically significantly lower than that in normal cervical tissue group( P<0. 05). In cervical squamous cell carcinoma group,the positive expression rate of N-cad in patients of stage Ⅱ was statistically significantly higher than that in patients of stage Ⅰ,the positive expression rate of N-cad in patients of grade 2-3 was statistically significantly higher than that in patients of grade 1( P<0. 05). There was no statistically significant difference in the positive expression rate of N-cad among the patients in different age groups and with lymph node metastasis or not( P> 0. 05). Conclusion The expression of N-cad is high in cervical cancer patients,which may be a new potential target molecule for treatment of cervical cancer.