| 微波在顶头孢霉菌选育中的应用 |
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| 引用本文： | 季惠军,孟广慧,姚远,郑国香,张新元. 微波在顶头孢霉菌选育中的应用[J]. 黑龙江医药, 2002, 15(3): 190-191 |
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| 作者姓名： | 季惠军 孟广慧 姚远 郑国香 张新元 |
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| 作者单位： | 哈药集团股份有限公司制药总厂,150086;哈药集团股份有限公司制药总厂,150086;哈药集团股份有限公司制药总厂,150086;哈药集团股份有限公司制药总厂,150086;哈药集团股份有限公司制药总厂,150086 |
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| 摘 要： | 头孢菌素 C 是半合成头孢菌素类抗生素的重要原料,通过对其产生菌顶头孢霉菌的诱变研究,能使发酵单位不断提高。本实验通过用微波诱变顶头抱霉菌 B_(42)节孢子,得到变株 B42—V2,单位提高16.03%,且遗传性状非常稳定。实验表明:微波诱变育种效果好、操作简便、所选育菌株遗传性状稳定。
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| 关 键 词： | 头孢菌素C 顶头抱霉菌 微波诱变 节抱子 |
| 修稿时间： | 2001-12-05 |
An Application of Microwave on Selection of Cephalosporium acremonium |
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| Ji Huijun,General Pharm.Factory,Harbin Pharmaceutical Group Co.Ltd. An Application of Microwave on Selection of Cephalosporium acremonium[J]. Heilongjiang Medicine, 2002, 15(3): 190-191 |
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| Authors: | Ji Huijun General Pharm.Factory Harbin Pharmaceutical Group Co.Ltd |
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| Abstract: | Cephalosporin C is an important material for antibiotics of semi-composed Cephalosporin family,the yields of Cephalosporin Cwill be gradually increased through selection of Cephalosporium acremonium.Mutant B42-V2 with better genetic stability was obtained and 16.3 percent of yields was increased by inducing Cephalosporium acremonium B42 with mi- crowave irradiation in this experiment.Experiment shows that microwave irradiation has features of good result,easy operation and stability for mutant selected. |
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| Keywords: | Cephalosporin C Cephaiosporium acremonium Microwave irradiation Arthrospore |
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