| 大肠癌对铂类药物的耐药机制 |
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| 引用本文： | 邵卉,白元松,卢振霞. 大肠癌对铂类药物的耐药机制[J]. 国际肿瘤学杂志, 2008, 35(4) |
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| 作者姓名： | 邵卉 白元松 卢振霞 |
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| 作者单位： | 吉林大学中日联谊医院血液肿瘤内科,长春,130033 |
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| 摘 要： | 铂类药物是大肠癌化疗常用的药物之一,但仍存在耐药问题而影响疗效,因此研究肿瘤细胞的铂类耐药机制是大肠癌治疗研究的热点,包括药物蓄积降低、DNA修复机制、形态学变化等.
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| 关 键 词： | 结直肠肿瘤 铂化合物 抗药性 |
Mecbanism of platinum resistance in colorectal carcinoma |
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| Abstract: | Platinum is one of common chemotherapy drugs in colorectal cancer, but drug resistance influences the chemotherapy effect. Mechanism of platinum resistance in tumor cells is the focus research in colorectal cancer treatment, including defects in drug uptake, impaired DNA adduct formation, morphologic changes and so on. |
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| Keywords: | Colorectal neoplasms Platinum compounds Drug resistance |
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