18 F-FDG PET/CT显像联合血清肿瘤标志物检测在肺单发结节诊断中的价值

目的 探讨18F-FDG PET/CT显像和血清肿瘤标志物(CEA、NSE、CFRA21-1)检测联合在肺单发结节诊断中的价值.方法 91例经病理确诊的肺单发结节患者进行18F-FDG PET/CT显像,同时取静脉血4mL分离取血清在低温冰箱保存,用放免法集中测量血肿瘤标志物CEA、NSE、CFRA21-1.结果 18 F-FDG PET/CT检查对肺单发结节恶性肿瘤检出的灵敏度为84.8%(56/66),对肺单发结节诊断的准确率为86.8%(79/91);18 F-FDG PET/CT显像联合血肿瘤标志物(CEA+NSE+CFRA21-1)检测对肺单发结节恶性肿瘤检出的灵敏度为93.9%(62/66),对肺单发结节诊断的准确率为95.6%(87/91),和18F-FDG PET/CT检查相比,灵敏度和准确率差异具有统计学意义(P均﹤0.05).结论 18 F-FDG PET/CT显像和血肿瘤标志物(CEA、NSE、CFRA21-1)检测联合能提高对肺单发结节诊断的灵敏度和准确性,有较高的临床应用价值.

The Clinical Value of 18F-FDG PET/CT Imaging Combined with Serum Tumor Markers in the Diagnosis of Single Lung Nodules

Objective To estimate clinical value of 18F-FDG PET/CT imaging combined with serum tumor markers(CEA,NSE,CFRA21-1)in the diagnosis of single lung nodules.Methods 91 cases of patients with single lung nodules confirmed by pathologic results received 18F-FDG PET/CT imaging.At the same time, 4mL of venous blood was collected and the serum was stored in the freezer.The serum levels of tumor markers CEA,NSE,CFRA21-1 were then measured by radioimmunoassay method.Results The sensitivity of the 18F-FDG PET/CT examination was 84.8%(56/66)for the detection of malignant tumor of lung single nodules,and the accuracy of the diagnosis of pulmonary single nodules was 86.8%(79/91);The sensitivity of the 18F-FDG PET/CT imaging combined with blood tumor markers(CEA +NSE +CFRA21-1)was 93.9%(62/66)for the detection of pulmonary single nodular malignancy,and the accuracy of the diagnosis of pulmonary single nodules was 95.6%(87/91).Compared with 18F-FDG PET/CT,the sensitivity and accuracy of combination method were significantly different(P<0.05).Conclusion The 18F-FDG PET/CT imaging combined with blood tumor markers(CEA +NSE +CFRA21-1)can improve the sensitivity and accuracy of PET/CT imaging in the diagnosis of pulmonary single nodules,with high clinical values.