血清白蛋白水平与冠心病严重程度的关系(英文)

目的:探讨血清白蛋白水平与冠心病严重程度的关系。方法:选择2008～2009年我院住院,行冠脉造影的患者237例,分别按临床类型、冠脉病变支数及冠脉病变积分评价冠心病严重程度,并分为非冠心病组(84例)、心绞痛组(92例),心肌梗死组(61例),入院第二天测定所有患者血清总蛋白、白蛋白及球蛋白,分析各指标与蛋白之间的相关性。结果:与非冠心病组比较,心绞痛组和心肌梗死组白蛋白水平明显降低[(40.22±3.56)g/L比(39.81±3.56)g/L比(38.68±3.43)g/L,P<0.05]。Spearman相关分析显示:血清白蛋白水平与临床类型(r=-0.18,P=0.005)、冠脉病变支数(r=-0.195,P=0.003)及冠脉病变积分(r=-0.188,P=0.004)呈显著负相关,而总蛋白、球蛋白及白球比值与临床类型、冠脉病变支数及冠脉病变积分均无显著相关(P>0.05)。结论:血清白蛋白水平与冠心病的严重程度呈负相关,白蛋白偏低可能是冠心病的危险因素。

Relationship between serum albumin level and severity of coronary heart disease

Objective： To investigate the relationship between serum albumin level and severity of coronary heart dis- ease （CHD）. Methods： A total of 237 patients admitted in our hospital from 2008 to 2009 and undergoing coronary angiography were enrolled. CHD severity was evaluated according to clinical types, number of diseased coronary vessels and coronary artery score respectively, and patients were divided into non--CHD group （n= 84）, angina pectoris group （n= 92） and myocardial infarction group （n= 61）. Serum total protein, albumin and globulin were measured in all patients on second day after admission. Relationship among indexes of CHD severity and serum pro- teins were analyzed. Results： Compared with non--CHD group, there was significant decrease in albumin level [- （40.22_＋3.56） g/L vs. （39.81-＋-3.56） g/L vs. （38.68~3.43） g/L, P〈O. 05] in angina pectoris group and myo- cardial infarction group. Spearman correlation analysis indicated that serum albumin level was significant negatively correlated with clinical types （r = --O. 18, P= O. 005）, number of diseased coronary vessels （r = --O. 19＇5, P = O. 003） and coronary artery score （r =- 0. 188, P = O. 004）. Serum total protein, globulin and ratio of albumin/ globulin were not significantly correlated with clinical types, number of diseased coronary vessels and coronary arter- y score （P〉0. 05）. Conclusion： Serum albumin level is negatively correlated with severity of coronary heart disease. Low serum albumin may be a risk factor for coronary heart disease.