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| CAR-T在甲状腺癌免疫治疗中的研究进展 | |
| 引用本文： | 贾永胜, 郑向前, 张艳. CAR-T在甲状腺癌免疫治疗中的研究进展[J]. 中国肿瘤临床, 2023, 50(17): 910-914. DOI: 10.12354/j.issn.1000-8179.2023.20230569 |
| 作者姓名： | 贾永胜 郑向前 张艳 |
| 作者单位： | 天津医科大学肿瘤医院甲状腺颈部肿瘤科，国家恶性肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心（天津市300060） |
| 摘 要： | 大多数甲状腺癌患者进行以外科治疗为主的综合治疗可以取得良好的预后，但目前晚期甲状腺癌治疗手段匮乏。采用体外基因编辑技术的嵌合抗原受体T细胞（chimeric antigen receptor T-cell，CAR-T）免疫疗法在血液系统肿瘤中得到应用并取得了良好的治疗效果。以此为基础，CAR-T开始在实体肿瘤中尝试使用，但效果欠佳。CAR-T在晚期甲状腺癌中的研究已有开展，目前仍局限在临床前的基础研究，相关临床试验较少且缺乏试验结果报道。本文将相关报道进行综述，旨在为今后的研究提供参考。 |
| 关 键 词： | 甲状腺癌 嵌合抗原受体T细胞 免疫治疗 |
| 收稿时间： | 2023-06-20 |
| 修稿时间： | 2023-09-07 |
Updates on the management of thyroid cancer |
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| Yongsheng Jia, Xiangqian Zheng, Yan Zhang. Research progress of CAR-T therapy in the management of thyroid cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2023, 50(17): 910-914. DOI: 10.12354/j.issn.1000-8179.2023.20230569 | |
| Authors: | Yongsheng Jia Xiangqian Zheng Yan Zhang |
| Affiliation: | Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China |
| Abstract: | The majority of patients with thyroid cancer can attain a favorable prognosis following surgery; however, this is not the case for advanced thyroid cancer. Chimeric antigen receptor T-cell (CAR-T) immunotherapy has demonstrated successful outcomes in hematological tumors. Building upon this success, researchers have explored the application of CAR-T therapy in solid tumors, yet the results have been less than optimal. Although research into CAR-T for advanced thyroid cancer is underway, it remains primarily in the realm of basic research, with limited clinical trials and inconclusive outcomes. In this review, we examine pertinent reports to offer insights for future research endeavors. |
| Keywords: | thyroid cancer chimeric antigen receptor T-cell (CAR-T) immunotherapy |
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