微波固化保肢术后成骨肉瘤患者红细胞免疫功能的变化

研究微波固化保肢术提高患者生存率的免疫学机制。方法应用色散比浊法检测患者血清Ｃ３、Ｃ４含量，应用红细胞Ｃ３ｂ受体花环、免疫复合物花环及直接肿瘤花环检测红细胞免疫功能。

Impact on Erythrocytic Immunity following Microwave Treated Limb - salvage Treatment in Patients with Osteogenic Sarcoma

Objective: To observe the effect of limb -salvage and microwave tissue coagulation(MTC) on immune function in patients with osteogenic sarcoma. Methods: The erythrocyte immune func-tion of osteogenic sarcoma patients was tested with C3b receptor rosette (C3bRR) , red blood cell immunecomplex rosette (CICRR) and tumor cell red blood cell rosette (TRR) . The serum C3, C4 contents wereexamined by chromatic dispersing turbidity method. Results: In all patients C3bRR and TRR declinedmarkedly, while CICRR elevated ( P<0.05). No significant changes of C3, C4 were observed. On thefourteenth postoperative day , the C3bRR, TRR in the MTC group elevated higher than those in the amputa-tion group (P<0.05), but no prominent change of CICRR was seen. On the 28th postoperative day,all the data of these two groups returned normal (P<0.05) . Conclusion: Limb - salvage in conjunc-tion with microwave coagulation may enhance the immune function of the patients with osteogenic sarco-ma.