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| 苯接触标志物尿中苯巯基尿酸的分析与评价 | |
| 引用本文： | 罗巧,朱长才,宋世震. 苯接触标志物尿中苯巯基尿酸的分析与评价[J]. 卫生研究, 2008, 37(1): 106-108 |
| 作者姓名： | 罗巧 朱长才 宋世震 |
| 作者单位： | 武汉科技大学医学院劳动卫生教研室,武汉,430065 |
| 摘 要： | 尿中苯巯基尿酸(SPMA)与苯接触存在良好相关性,是低浓度苯接触特异和敏感的生物标志物。SPMA可用高效液相色谱法(HPLC)、液质联谱(LC/MS)、气质联谱(GC/MS)和酶联免疫吸附试验(ELISA)等方法检测。本文详细介绍了国外检测尿SPMA的方法,评价了尿SPMA作为职业苯接触生物标志物的有效性和应用。 |
| 关 键 词： | 苯 尿中苯巯基尿酸 生物监测 职业中毒 |
| 文章编号： | 1000-8020（2008）01-0106-03 |
| 收稿时间： | 2007-02-26 |
| 修稿时间： | 2007-02-26 |
Analysis and evaluation of S-phenylmercapturic acid as a biomarker for benzene exposure |
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| LUO Qiao,ZHU Changcai,SONG Shizhen. Analysis and evaluation of S-phenylmercapturic acid as a biomarker for benzene exposure[J]. Journal of hygiene research, 2008, 37(1): 106-108 | |
| Authors: | LUO Qiao ZHU Changcai SONG Shizhen |
| Affiliation: | Department of Occupational Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China. luoqiao82@gmail.com |
| Abstract: | Since urinary S-phenylmercapturic acid concentration could be well related to benzene exposure, it could be a sensitive and specific biomarker of low-level benzene exposure. SPMA may be determined by HPLC, LC/MS, GC/MS and ELISA methods. The abroad methods of determination of urinary SPMA were reviewed in detail in recently years and the validation and application of urinary SPMA as a biomarker for occupation benzene exposure were evaluated. |
| Keywords: | benzene urinary S-phenylmercapturic acid biological monitoring occupational poisoning |
| 本文献已被 维普 万方数据 等数据库收录！ | |