新生儿感染IgG亚类探讨

本文观察18例新生儿败血症及11例新生儿皮下坏疽IgG亚类变化,两组患婴的四种血清IgG亚类均低于对照组(p<0.01或<0.05)。体外用pwm诱导B细胞产生lg可见两组患婴除lgM如lgG_3,外,IgG_1、lgG_2及lgG_4,明显低于对照组(p<0.01或p<0.05)。患婴的PBMC对T细胞丝裂原PHA的增殖反应减弱,CD_4/CD_8比值下降。本文结果表明新生儿感染时T细胞功能系乱可致B细胞抗体生成能力下降。

STUDY ON IgG SUBCLASSES IN NEONATAL INFECTIONS

The patterns of IgG subclasses in 18 cases of neonatal sepsis and 11 cases of neonatal subcutaneous gangrene were studied. Compared with those in 18 age - matched normal controls, all serum IgG subclasses (including IgG1 ,IgG2,IgG3and Igg4)in the both groups of the patients were statistically decreased(P<0. 01or P<0. 05). The ability of in vitro iminunoglobulin biosynthesis was observed with Tcell dependent mitogen(pokeweed mito-gen). The results showed that the concentrations of IgG1 ,Igg2and Igg4 in the supernntants of 10 -day cultured peripheral blood mononuclear cbllsfrom the patients with sepsis and subcutaneous gangrene were, lower than thosefrom normal controls. The Lymphocyte proliferative response to PHA and ratio of CD4/CD8in the patients were also decreased significantly in comparison with the normal controls. It is suggested that T cell dysfunction in neonatal infections might be related to the abnormal IgG subclass productions.