颈动脉粥样硬化斑块及血脂与脑梗死的相关研究

目的探讨颈动脉粥样硬化斑块、血脂与脑梗死（CI）之间的关系。方法对117例脑梗死患者、98例体检健康人群进行血脂测定和颈动脉粥样硬化斑块检测,并行对照分析。结果脑梗死组中伴颈动脉粥样硬化斑块患者明显多于对照组,且以不稳定斑块患者为主,颈动脉分叉处（BIF）常见。不稳定斑块组的总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）水平明显高于对照组。脑梗死组的TC、TG、LDL-C载脂蛋白B（ApoB）水平均明显高于对照组,高密度脂蛋白胆固醇（HDL-C）水平明显低于对照组。不同年龄脑梗死患者的血脂水平无明显差异。结论血清TC、TG、LDL水平与颈动脉粥样硬化斑块稳定性有关。血脂异常是独立于年龄之外的脑梗死和颈动脉粥样硬化的重要危险因素。

The Relationship between Serum Lipid and carotid atherosclerosis in patients with cerebral infarction

Objective To investigate the relationship among carotid atherosclerosis plaque, cerebral in farction and lipid. Methods Serum lipid levels and Color Doppler Ulerasound were measured in 117 patients with cerebral infarction and 98 normal controls. Results The cerebral infarction patients had a high incidence of carotid atheroselerosis plaque, especially the incidence of vulnerable plaque. TC, TG, and LDL-C were higher in patients with vulnerable plaque （VP） than other patients. Significant higher serum TC, TG, ApoA1, and ApoB were found in patients with cerebral infarction when compared with normal controls （P 〈0. 05）. Conclusions There was close relationship between TC,TG, LDL-C and stability of plaque. The abnormality of lipid had significant influence on cerebral infarction and carotid atherosclerosis,which was not associated with age.