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电针对帕金森病大鼠纹状体谷氨酸含量的影响
引用本文:马骏,田青,王彦春,王华. 电针对帕金森病大鼠纹状体谷氨酸含量的影响[J]. 上海针灸杂志, 2003, 22(1): 36-36
作者姓名:马骏  田青  王彦春  王华
作者单位:湖北中医学院,武汉,430061;湖北中医学院,武汉,430061;湖北中医学院,武汉,430061;湖北中医学院,武汉,430061
摘    要:目的 观察帕金森病 ( PD)大鼠纹状体中兴奋性氨基酸谷氨酸 ( Glu)含量的变化以及电针的影响。方法 建立单侧黑质毁损的帕金森病大鼠模型 ,观察正常组、假手术组、模型组、电针组大鼠双侧纹状体谷氨酸含量。结果 电针可显著降低 PD大鼠毁损侧纹状体 Glu含量 ( P<0 .0 5 )。结论 兴奋性氨基酸参与了 PD的发病过程 ,减少兴奋性氨基酸的释放是电针治疗PD的作用途径之一

关 键 词:帕金森病  电针  大鼠  纹状体  氨基酸类  动物  实验
文章编号:1005-0957(2003)01-0036-02
修稿时间:2001-09-23

Influence of Electro acupuncture on the Content of Glutamine in Striatum of Parkinson''''s Disease Rats
MA Jun,TIAN Qing,WANG Yan-chun,WANG Hua Hubei College of Traditional Chinese Medicine,Wuhan ,China. Influence of Electro acupuncture on the Content of Glutamine in Striatum of Parkinson''''s Disease Rats[J]. Shanghai Journal of Acupuncture and Moxibustion, 2003, 22(1): 36-36
Authors:MA Jun  TIAN Qing  WANG Yan-chun  WANG Hua Hubei College of Traditional Chinese Medicine  Wuhan   China
Affiliation:MA Jun,TIAN Qing,WANG Yan-chun,WANG Hua Hubei College of Traditional Chinese Medicine,Wuhan 430061,China
Abstract:Objective To observe the influence of eletro-acupuncture on the glutamine(Glu) in the striatum of Parkinson's disease(PD) rats, Methods The rat model of PD was established by injuring the unilateral nigra. The contents of Glu in the bilateral striatum in normal group, sham operation group, electro-acupuncture group and model group were assessed. Results Electro-acupuncture could reduce the content of Glu obviously(P<0.05). Conclusion Glu has a close relation with the development of PD, and electro-acupuncture can reduce the release of Glu to treat PD.
Keywords:Parkinson disease  Electroacupuncture  Rats  Corpus striatum  Amion acid  Animals   laboratory
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