精神分裂症患者迟发性运动障碍与糖代谢异常关系探讨

目的 探讨迟发性运动障碍(TD)与糖代谢之间可能存在的关系.方法 采用Simpson迟发性运动障碍专用量表筛选出符合入组标准的TD患者(TD组)30例和非TD患者(非TD组)32例,采用阳性与阴性症状评定量表(PANSS)评定精神病理症状的严重程度,采用异常不自主运动量表(AIMS)评定TD症状的严重程度,采用全自动生...

Relationship between glycometabolism and tardive dyskinesia in schizophrenia patients

Objective To explore the relationship between glycometabolism and tardive dyskinesia in schizophrenia patients. Methods Thirty schizophrenia patients with TD and 32 without TD were recruited by using the Simpson dyskinesia scale. They were assessed with the Positive and Negative Symptom Scale ( PANSS ) and Abnormal Involuntary Movement Scale ( AIMS ) ( Chinese version ). The levels of FINS ( fasting insulin ), IRI( insulin resistance index ), GHB( glycolated hemoglobin )and FPG( fasting plasma glucose )were measured. The relationship between glycometabolism and TD was analysed. Results The levels of FPG were significantly higher in schizophrenia patients with TD [( 5.74 ± 1.36 )mmol/L] than the patients without TD[( 5.05 ± 0. 91 )mmol/L] ( F = 6. 619, P = 0. 013 ). The AIMS scores were positively correlated with levels of FINS( r = 0. 469, P ＜ 0. 05 ), FPG( r = 0. 512, P ＜ 0. 05 )and IRI( r = 0. 483, P ＜0. 05 ). Conclusions Glycometabolism may be involved in the pathophysiological process of TD.