恩丹西酮、地塞米松预防腹腔镜胆囊切除术后恶心呕吐的临床观察

目的：观察恩丹西酮、地塞米松预防腹腔镜胆囊切除术后恶性呕吐的临床效果和副作用。方法：60例择期行腹腔镜胆囊切除术成年患者，随机分为A、B、C三组每组20例，于麻醉诱导前3分钟A组注入恩丹西酮8mg,B组注入地塞米松10mg，C组注入生理盐水10ml。观察术后24小时患者恶性呕吐的发生情况及MAP、HR、RR、SpO2变化情况。结果：A、B组恶性呕吐发生率明显小于C组（P＜0．01），A组与B组之间无明显差异（P＞0．05），各组MAP、HR、RR、SpO2在正常范围内，无明显差异。结论：恩丹西酮和地塞米松预防腹腔镜胆囊切除术恶性呕吐的效果都比较明显，副作用都比较小。

The clinieal observation of preventing postoperative nausea and vomiting by using ondansetron and dexamethasone in laparoscopic cholecy stectomy

Objective: To observe the clinical effectiveness and side effect of ondansetron and dexamethasone(DXM) preventing PONV in laparoscopic cholecy stectomy.Methods:60 cases of operating laparoscopic cholecy stectomy were randomly dibided into three groups(A?B?C).Each group had 20 cases In 3 minutes before anesthesia induction,8mg ondansetrom were injected into in A group,10mg DXM injected in B group,10ml physiological saline injected in C group.We observed patients'nausea and vomiting?MAP?HR?RR and SpO 2.Results:The rate of nausea and vomiting in A?B gronps was less.than that of C group(P<0.01).There was no indifference between A and B.MAP?HR?RR?SpO 2 were normal in all growps,there was no notable indnfference(P>0.05).Conclusion:The effectiveness of ondansetron and DXM preventing postoperative nausea and vomiting in laparoscopic cholecy stectomy was notable.