Gallbladder carcinoma: analysis of prognostic factors in 132 cases

Objective: To evaluate the prognostic factors of gallbladder carcinoma. Methods: Presentation, operativedata, complications, and survival outcome were examined for 132 gallbladder carcinoma patients who underwentgallbladder surgery in our unit during 2002-2007, and follow-up results were obtained from every patient forunivariate and multivariate survival analysis. Results: The univariate analysis showed that gallbladder lesionhistory, tumor cell differentiation, Nevin staging, preoperative lymph node metastasis and the surgical approachsignificantly correlated with the prognosis of the patients (p <0.05). The results of the multivariate analysis (Coxregression) showed that gallbladder lesion history, Nevin staging and the surgical approach were independentpredicators with relative risks of 6.9, 4.4, 2.8, respectively (p=0.002, 0.003, 0.008). Conclusion: Gallbladder lesionhistory, Nevin staging and the surgical approach are independent prognostic factors for gallbladder carcinoma,a rapidly fatal disease. Therefore, early diagnosis, anti-infective therapy and radical surgery are greatly neededto improve the prognosis of gallbladder carcinoma.