Osteoclast-like giant cell tumor of the pancreas: an immunohistochemical and ultrastructural study |
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| Authors: | Fujihiko Suzuki Akira Saito Kazuhisa Ishi Koichiro Yamanaka Toshihide Maruyama Masaki Fukunaga Michio Matsumoto Masanobu Eguchi Yoshinori Hosokawa Koichi Suda |
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| Affiliation: | (1) Clinical Laboratory, Juntendo University School of Medicine, Urayasu Hospital, 2-1-1 Tomioka, Urayasu, 279 Chiba, Japan;(2) Department of Internal Medicine, Juntendo University School of Medicine, Urayasu Hospital, Chiba, Japan;(3) Department of Surgery, Juntendo University School of Medicine, Urayasu Hospital, Chiba, Japan;(4) Department of Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113 Tokyo, Japan |
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| Abstract: | ![]()
We report a rare case of osteoclast-like giant cell tumor of the pancreas in a 70-year-old Japanese woman. The tumor was composed of a proliferation of ovoid to spindle-shaped mononuclear cells admixed with osteoclast-like giant cells. The tumor cells were immunore-active for vimentin, ±1-antitrypsin, and CD68. In ultrastructural examination, the giant cells resembled osteoclasts, and the mononuclear stromal cells had fibroblastic and histiocytic features. No elements of epithelial differentiation were found in this tumor. These findings suggest that this tumor had a derivation similar to giant cell tumor of bone.This study was presented at the 28th Annual Meeting of the Clinical Electron Microscopy Society of Japan, Osaka, October 17–19, 1996. |
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| Keywords: | Osteoclast-like giant cell tumor Pancreas Immunohistochemistry Electron microscopy |
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