中心性浆液性脉络膜视网膜病变患者荧光素眼底血管造影特征

目的　分析中心性浆液性脉络膜视网膜病变（CSC）患者荧光素眼底血管造影（FFA）特征。方法　回顾分析FFA确诊的598例CSC患者640只眼的临床资料。所有患者均进行视力、裂隙灯显微镜、直接检眼镜检查并采用德国海得堡眼底造影系统行绿色激光扫描眼底照相及FFA检查。观察视网膜色素上皮（RPE）渗漏点发生的部位并分析其特点，统计测量其年龄、视力、视网膜神经上皮脱离面积、RPE渗漏形态并分析其相关性。结果　渗漏灶集中发生于后极部，上方象限多于下方象限，差异有统计学意义（χ2=67.13,P＜0.01）；鼻侧多于颞侧象限，差异有统计学意义（χ2=20.93,P＜0.01）；距中心凹距离越近渗漏灶发生频率越高，差异有统计学意义（χ2=212.715,P＜0.01）。渗漏灶形态分析发现渗漏灶形态与年龄有关。64例≥50岁患者中微漏型35例，占该组患者的54.7%；154例35～39岁患者中扩散型82例，占该组患者的53.2%；多渗漏灶浆液性视网膜脱离面积小，单渗漏灶浆液性视网膜脱离面积大，两者差异无统计学意义(F=1.925，P＞0.05) ；CSC患者视力与浆液性视网膜神经上皮脱离面积呈负相关（r=-0.335，P＜0.01）,与病程及渗漏灶距中心凹距离无相关性(r=-0.029，-0.145；P＞0.05)。结论　CSC患者FFA渗漏灶的发生有区域性差别，浆液性视网膜脱离面积与渗漏灶多少无关。

The characteristics of images of fundus fluorescein angiography in patients with central serous chorioretinopathy

Objective To analyze the characteristics of images of fundus fluorescein angiography (FFA)in patients with central serous chorioretinopathy(CSC).Methods We observed the positions of leakage spots of retinal pigment epithelium(RPE)and analyzed their characteristics in 598 CSC patients.The ages,visual acuty,detachment areas of sensory retina,and leakage patterns of RPE were recorded and the correlation of them were analyzed.Results The leakage concentrated in the posterior pole,which occurred more frequently in the superior quadrant,nosal quadrant,and near fovea regions than in the inferior quadrant,temporal quadrant,and far regions from fovea,respectively(X~2=67.1 3,20.93,212.715;P<0.01).We found that there were relations between the ages of patients and the patterns of the leakage.A total of 35 patients(54.7%out of 64)at the age of≥50 had small leakage;82 patients(53.2% out of 154)at the age of 35-39 had diffusing leakage.Smaller retinal detachment in patients with multiple serous leakage and bigger retinal detachment area in patients with single serous leakage were found;no statistical significance was found(F=1.925,P>0.05).There was negative correlation between the visual acuity and the detachment area in CSC patients(t=-0.335,P<0.01),and there was no correlation between the visual acuity and the distances from the leakage spots to the fovea(t=-0.029,-0.145;P>0.05).Conclusion The leakages occurs in various regions whose difference is significant;the patterns of leakage are related to the ages;there is no relation between the serous retinal detachment area and the number of the leakage.