Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. |
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| Authors: | M M Hreshchyshyn B S Aron R C Boronow E W Franklin H M Shingleton J A Blessing |
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| Affiliation: | 1. Professor of Radiology, Director, Division of Radiation Therapy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, U.S.A.;2. American Cancer Society, Professor of Clinical Oncology, USA |
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| Abstract: | ![]()
In a prospective study by the Gynecologic Oncology Group (GOG), 104 evaluable patients with cervical squamous cell carcinoma Stages IIIB and IVA were randomly assigned to treatment with hydroxyurea or placebo in combination with radiation. There were no deaths resulting from the treatment. Hematologic toxicity was more common and more severe in patients who received hydroxyurea. Response was evaluated in terms of complete tumor regression, duration of progression-free interval and survival probability. By all those parameters the response was significantly better in the groups of patients receiving hydroxyurea. |
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| Keywords: | Carcinoma of the cervix Hydroxyurea Radiation |
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