光动力疗法治疗脉络膜裂伤伴中心凹下新生血管的疗效观察

目的观察光动力疗法治疗脉络膜裂伤伴中心凹下新生血管的临床效果。方法经矫正视力、裂隙灯显微镜、眼底、荧光素眼底血管造影和吲哚菁绿血管造影检查确诊为黄斑区脉络膜裂伤伴脉络膜新生血管患者9例9只眼。静脉注射维替泊芬6 mg/m2,15 min后以波长689 nm、功率密度600 mW/cm2、能量密度50 J/cm2、时间83 s激光照射病灶,随访12个月。对比分析治疗前后患者的视力、病灶大小和脉络膜新生血管渗漏变化。结果 3只眼视力提高,6只眼视力稳定,无视力下降。荧光素眼底血管造影联合吲哚菁绿血管造影检查显示,3只眼渗漏消失或减轻,病灶范围缩小,6只眼渗漏无明显变化,所有患眼未见渗漏扩大。治疗后1个月脉络膜出血明显吸收,3个月出血完全吸收,病灶边缘色素沉着,12个月所有患者脉络膜新生血管渗漏未见进一步扩大,无再次出血和病灶纤维化。结论光动力疗法可作为治疗脉络膜裂伤伴中心凹下新生血管的选择。

Photodynamic therapy for choroidal neovascularization secondary to choroidal rupture after blunt trauma

Objective To describe photodynamic therapy(PDT) as a treatment of subfoveal choroidal neovascularization(CNV) secondary to choroidal rupture in case of blunt trauma. Methods Clinical data of 9 patients who had undergone PDT because of the subfoveal CNV following traumatic choroidal rupture,which had been diagnosed by examination of ocular fundus,fluorescein angiography(FFA) and indocyanine green angiography(ICGA),were retrospectively analyzed.The best-corrected visual acuity,size of the lesion,and leakage o...