MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer |
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| Authors: | Fang Zhang Zhiping Yang Minjun Cao Yinsheng Xu Jintao Li Xuebin Chen Zhi Gao Jing Xin Shaomei Zhou Zhixiang Zhou Yishu Yang Wang Sheng Yi Zeng |
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| Affiliation: | 1. Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, PR China;2. Department of Gastroenterology, Affiliated Hospital of University of North China, PR China;3. Department of Thoracic Surgery, Beijing Friendship Hospital, PR China |
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| Abstract: | ![]()
The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21. |
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| Keywords: | Esophageal cancer MiR-203 MiR-21 Ran Tumor suppressor |
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