乳腺浸润性导管癌预后相关因素分析

目的:探讨乳腺浸润性导管癌预后相关因素.方法: 收集130例乳腺浸润性导管癌资料,回顾性分析其临床特征、病理分化程度、复发转移情况、激素受体状况、人类表皮生长因子受体2的表达、临床治疗及生存情况.结果: c-erbB-2表达在ER、PR阳性组低于ER、PR阴性组(P<0.01),ER表达在PR阳性组高于PR阴性组(P<0.01);中、低分化与高分化相比,在淋巴结的转移、肿瘤的转移或复发、临床分期、肿块的大小上,均有统计学差异(P<0.05);单因素分析结果显示,激素受体状况、人类表皮生长因子受体2表达、病理分化程度、淋巴结状况、肿瘤转移或复发、临床分期、肿瘤大小、T分期、N分期、辅助化疗等11个因素与预后相关;多因素分析结果显示:ER状况、病理分化程度、淋巴结状况、临床分期是乳腺浸润性导管癌患者预后的独立影响因素.结论: 对乳腺浸润性导管癌,早期发现并针对病理分化程度及激素受体水平的适当治疗是提高生存期的关键.

Analysis of the factors related to prognosis of breast invasive ductal carcinoma

Objective:To investigate the factors related to prognosis of breast invasive ductal carcinoma. Methods: To analyz retrospectively the correlative clinical data including characteristics,relapse,histogical grade and survival of the patients and the expression of ER,PR,c-erbB-2 in 130 cases of breast invasive ductal carcinoma. Results: The expression of c-erbB-2 in the group of ER or PR with positive expression was higher than that with negative expression(P<0.01).The expression of ER in the group of PR which with positive expression was higher than that with negative expression(P<0.01);GradeⅠof breast invasive ductal carcinoma was significantly higher than gradeⅡ or Ⅲ in lymph node metastasis,clinical stage,tumor size and tumor recurrence(P<0.05);The result of one-way analysis variance showed that the expression of ER,PR and c-erbB-2,histological grade,lymph node state,tumor recurrence,tumor size,T stage,N stage,and adjuvant chemotherapy were related to prognosis;The result of multivative COX regression showed that the expression of ER,histological grade,clinical tumor stage were the independent factors of prognosis. Conclusion: early diagnosis,treatment,histological grade and expression of endocrine are very important to enhance the survival time of breast invasive ductal carcinoma.