Effect of Melatonin, Ascorbic Acid, and Succinic Acid on the Cumulative Toxic Effect of Repeated Treatment with Gammafos (Amifostine) |
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Authors: | M. V. Vasin I. B. Ushakov V. Yu. Kovtun S. N. Komarova L. A. Semenova |
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Affiliation: | State Research Test Institute of Military Medicine, Russian Ministry of Defense, Moscow. |
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Abstract: | Daily treatment of outbred albino mice with gammafos in radioprotective doses of 300 and 500 mg/kg for 4 days produced a cumulative toxic effect. This effect was not observed after decreasing the dose of gammafos to 100 mg/kg. Repeated peroral administration of melatonin and ascorbic acid in a dose of 200 mg/kg 30 min before treatment with gammafos reduced its cumulative toxic effect. Succinic acid in a dose of 100 mg/kg was ineffective under these conditions. The cumulative death time for 50% animals receiving gammafos alone or in combination with melatonin, ascorbic acid, and succinic acid was 3.08, 4.29, 4.06, and 2.97 days, respectively. |
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Keywords: | amifostine melatonin ascorbic acid succinic acid toxicity |
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