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IDENTIFICATION OF DERMORPHIN AND HYP6-DERMORPHIN IN SKIN EXTRACTS OF THE BRAZILIAN FROG PHYLLOMEDUSA RHODEI |
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| Authors: | PIER CARLO MONTECUCCHI ROBERTO DE CASTIGLIONE VITTORIO ERSPAMER |
| Abstract: | Methanol extracts of the skin of the Brazilian frog Phyllomedusa rhodei contain approximately equal amounts of dermorphin and its analogue Hyp6-dermorphin, two opiate-like heptapeptides. A unique feature of their sequence is the presence of a D-amino acid residue at position 2. Hyp6-dermorphin possesses a spectrum of central and peripheral bioactivity very similar to that of dermorphin. |
| Keywords: | D-amino acid dermorphin hydroxy proline Hyp 6-dermorphin mass spec trometry opiate-like peptides Phyllomedusa rodei skin purification procedures sequence analysis |