硫普罗宁治疗药物性肝病临床评价

目的 通过应用硫普罗宁治疗药物性肝病（DILD），观察患者临床表现及肝功能的变化，探讨其治疗DILD的疗效和安全性。方法 77例患者随机分为治疗组41例（3例因过敏而停止用药），硫普罗宁200mg加入10％葡萄糖液250mL静脉滴注，每日一次，疗程30d；对照组36例，给予肝炎灵及能量合剂等基础治疗，每日一次，疗程30d。治疗前后分别观察症状和体征、肝功能及B超检测肝脾大小。结果 硫普罗宁治疗后患者临床症状、肝功能均有显著改善。治疗组与对照组比较。显效率及总有效率均有显著性差异（P〈0．05）。治疗组中3例有不良反应，出现低热，皮肤瘙痒、发红，皮疹等，停药后自行缓解。结论 硫普罗宁在药物性肝病的治疗中，对肝功能的恢复有明显作用，而且安全，可作为目前治疗DILD的理想药物。

Clinical evaluation of tiopronin for treatment of drug-induced liver disease

OBJECTIVE To observe the changes of clinical situation and liver function of the drug-induced liver disease(DILD) treated by tiopronin,and to discuss the curative efficacy and security of tiopronin.METHODS 77 patients with DILD were randomized into either therapy group(41 cases,tiopronin 200mg daily for 30 d) or control group(36 cases,basal treatment such as energy mixture,daily for 30 d).The efficacy and safety were evaluated with clinical,biochemical parameters and the size of liver and spleen.RESULTS After 30 days treatment,the clinical sign and biochemical parameters were improved in tiopronin group.The efficiency was significantly higher in tiopronin group than that in control group(P<0.05).CONCLUSION Tiopronin,with a good tolerance and safety,has a sound efficacy in the improvement of clinical signs and hepatic functions of DILD patients.It is a perfect drug to treat DILD at present.