脑胶质瘤瘤周的1H-MRS分析

目的：探讨使用磁共振波谱（MRS）分析胶质瘤瘤周代谢物。材料与方法：回顾和分析经临床诊断或经手术病理证实的32例脑胶质瘤MR图像及1H-MRS资料，对瘤体水肿内外带和正常脑组织行1H-MRS分析，比较不同区域代谢物Cho、NAA、Cr的浓度和Cho/Cr、NAA/Cr、NAA/Cho的比值差异性。结果：正常脑组织、瘤周外带和内带的NAA/Cho比值分别为1.67±0.64、1.32±1.13和0.84±0.62，有统计学差异（P<0.05）；正常脑组织、瘤周外带和内带的Cho分别为13.28±3.49，15.66±8.13和16.38±7.77，无统计学差异（P>0.05）；正常脑组织、瘤周外带和内带的NAA分别为20.67±5.52，14.25±5.52和10.48±4.82，有统计学差异（P<0.05）；正常脑组织、瘤周外带和内带的Cr分别为11.82±3.77，10.10±3.49和10.51±5.18，无统计学差异（P>0.05）。结论：1H-MRS分析可以反映脑胶质瘤瘤周的NAA和NAA/Cho比值差异。

1H-magnetic resonance spectroscopy analysis of peri-tumor region in brain glioma

Objective： To study the value of 1H magnetic resonance spectroscopy（1H-MRS） in the peri-tumor edema region of brain glioma. Materials and Methods： MRI and MRS data of 32 patients confirmed by clinical or histopathologic results were analyzed retrospectively. MRS analysis data was obtained in the medial and lateral zones of peri-tumor regions and nor- mal brain regions. The concentration of Cho, NAA, Cr and the ratio of Cho/Cr, NAA/Cr, NAA/Cho in the lateral and medial edema regions of peri-tumor and normal brain regions were calculated. Results： NAA/Cho ratio of the normal brain regions, lateral and medial edema zones of peri-tumor was 1.67±0.64, 1.32±1.13, 0.84±0.62, respectively, there were significant differ- ence between them（P〈0.05）. The Cho concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 13.28±3.49, 15.66±8.13 and 16.38±7.77, respectively, there was no significant difference between them（P〉0.05）. The NAA concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 20.67±5.52, 14.25±5.52 and 10.48±4.82, respectively, there was significant difference between them （P〈0.05）. The Cr concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 11.82±3.77, 10.10±3.49 and 10.51±5.18, respectively, there was no significant difference between them（P〉0.05）. Conclusion： Different metabolic changes of NAA and NAA/Cho in the peri-tumor regions can be detected by using 1H-MRS.