婴幼儿纤维瘤病临床病理分析

目的探讨婴幼儿纤维瘤病（infantile fibromatosis，IF）的临床病理特点、治疗及预后。方法对3例IF的临床资料、病理切片和随访资料进行分析。结果3例中女性1例。初始发病年龄分别为1岁、3岁及9岁，就诊年龄分别4岁、16岁、及39岁；病变分别位于左臀、右手腕及左前臂软组织，前2例为术后复发来我院就诊。镜下见肿瘤均由分化好的梭形细胞构成，向周围的横纹肌及骨浸润；瘤细胞间见胶原纤维。瘤细胞免疫表型vimentin、SMA、MSA均阳性。结论IF为良性肌纤维肿瘤，但呈侵袭性生长，不易切净，易复发，应行扩大切除或加激素治疗及局部放射治疗。

Infantile fibromatosis: A clinicopathological study of 3 cases

Purpose To study the clinicopathological characteristics, treatment and prognosis of infantile fibromatosis(IF). Methods The clinical data, pathological sections and follow-up data were analyzed in 3 cases of IF. Results In 3 cases, one is girl and two are boys. When the masses were first observed, the boys were 3 and 9-years-old,and the girl was l year old. The lesions were located in the soft tissues of the left buttock,right wrist and left arm, in which two cases were recurrent cases after excision. Microscopically, tumor cells were benign spindle-shaped with large amounts of collagenous fiber, infiltrating residual skeletal muscle fibers and the bone. Immunohistochemical staining showed that tumor cells were positive for vimentin, SMA and MSA. Conclusions IF has benign morphology. But it can locally invasive and tends to recur after adequate excision. Complete excision with ample margins is the treatment of choice. There is relatively little information as to the efficacy of adjuvant chemotherapy or local radiotherapy.