结肠癌,胃癌患者贫血机理的研究

目的：探讨结肠癌、胃癌患者贫血的发病原因。方法：常规法系统地测定结肠癌、胃癌患者全血血红蛋白（Ｈｂ）、血浆游离Ｈｂ的浓度；全血铁、血浆铁含量；红细胞形态、计数；红细胞压积、红细胞渗透脆性试验、红细胞孵育渗透脆性试验；血浆蛋白质质和量的变化。并以正常人的血、血浆为对照。结果：全血血红蛋白、血浆铁、全血铁含量，红细胞计数、压积、血浆总蛋白、血浆白蛋白，癌症患者显著低于正常对照组。而血浆游离血红蛋白浓度，红细胞渗透脆性试验ＮａＣｌ浓度、红细胞孵育渗透脆性试验ＮａＣｌ－磷酸盐缓冲液浓度，癌症患者显著高于正常对照组。结论：各种癌症患者都有不同程度的贫血，原因是红细胞破坏太多、生成减少，癌肿溃烂出血。

STUDY ON THE MECHANISM OF ANEMIA IN CARCINOMAS OF COLON AND STOMACH

Objective: To detect the mechanism of anemia in carcinomas of colon and stomach. Methods: Hb and iron levels in whole blood and plasma, erythrocyte count, hematocrit, erythrocyte osmotic fragility and erythrocyte incubation osmotic fragility in carcinomas of colon and stomach were analysed systematically and compared with that of normal human's blood and plasma. Results: The Hb level in whole blood, iron levels in whole blood and plasma, erythrocyte count, hematocrit, plasma proteins and albumin in cancer patients were significantly lower than that of control. The plasma Hb level, the concentration of NaCl in erythrocyte osmotic fragility test, the concentration of NaCl phosphate-salt buffer in erythrocyte incubation osmotic fragility test in cancer patients were significantly higher than that of control. Conclusion: Cancer patients suffer from anemia in various degrees. The main causes of anemia of gastrointestinal cancer cases are increased erythrocyte destruction, decreased erythrocyte production and hemorrhage.