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| 脐血细胞神经分化与移植的研究进展 | |
| 引用本文： | 范存刚,韩忠朝. 脐血细胞神经分化与移植的研究进展[J]. 基础医学与临床, 2005, 25(9): 789-793 |
| 作者姓名： | 范存刚 韩忠朝 |
| 作者单位： | 中国医学科学院,中国协和医科大学,血液学研究所,血液病医院,天津,300020;北京大学人民医院,神经外科,北京,100044;中国医学科学院,中国协和医科大学,血液学研究所,血液病医院,天津,300020 |
| 基金项目： | 国家高技术研究发展计划项目（2002AA17041,2002AA223354,2003AA205060）;国家重点基础性研究项目（001CB5101）;CMB基金（#01-748） |
| 摘 要： | 自20年前Nakahata等发现人脐血中含有丰富的造血干细胞以来，脐血造血干，祖细胞的研究取得了很大的进展，并已成为一个新的造血干细胞来源。近来研究表明，脐血中的部分细胞在体外培养或体内移植后可分化为神经细胞，并可促进受损动物的神经功能恢复，本文将对脐血源神经细胞的研究进展进行探讨。 |
| 关 键 词： | 脐血 干细胞 分化 神经元 |
| 文章编号： | 1001-6325(2005)09-0789-05 |
| 收稿时间： | 2004-11-16 |
| 修稿时间： | 2005-02-21 |
Neural differentiation and transplantation of umbilical cord blood cells |
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| FAN Cun-gang,HAN Zhong-chao. Neural differentiation and transplantation of umbilical cord blood cells[J]. Basic Medical Sciences and Clinics, 2005, 25(9): 789-793 | |
| Authors: | FAN Cun-gang HAN Zhong-chao |
| Abstract: | Research in cord blood derived hematopoietic stem/progenitor cells has had a fast advance since Nakahata reported that human umbilical cord blood was rich in hematopoitic stem cells 20 years ago. Umbilical cord blood has currently become a new source of hematopoietic stem cells. Recent studies also indicated that a proportion of cord blood cells could be induced into neural phenotypes under permissive in vitro. After administration into animal models of neurological diseases, these cells could differentiate into neural cells and improve functional recovery of animals. In this article, we reviewed the findings and prospects of umbilical cord blood derived neural cells. |
| Keywords: | umbilical cord blood stem cell: differentiation neuron |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |