| 复方三酮脑通片对MCAO大鼠脑组织形态学的影响 |
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| 引用本文： | 李贵海,孙付军,王世军.复方三酮脑通片对MCAO大鼠脑组织形态学的影响[J].中药材,2006,29(12):1329-1332. |
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| 作者姓名： | 李贵海 孙付军 王世军 |
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| 作者单位： | 1. 山东省中医药研究院,山东,济南,250014
2. 山东中医药大学,山东,济南,250014 |
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| 摘 要： | 目的:试验观察复方三酮脑通片对MCAO大鼠脑组织形态学改变的影响,探讨其对缺血性脑血管疾病脑组织形态学的保护作用。方法:采用栓线法复制大脑中动脉栓塞(MCAO)模型,造模成功后随机分为六组给药,HE切片观察脑组织细胞形态学及脑梗死面积的变化,并采用免疫组化技术对脑血管内皮细胞与神经细胞的诱导型一氧化氮合酶(iNOS)的表达进行检测。结果:在MCAO大鼠急性脑缺血恢复过程中,复方三酮脑通片明显降低海马CA1区神经元细胞的死亡率及神经细胞iNOS的表达,促进局部微血管的生成,加速MCAO大鼠脑功能的恢复。结论:复方三酮脑通片能够降低急性脑缺血MCAO大鼠脑缺血局部神经元的死亡率。促进局部微血管的生成,改善脑组织微循环,并下调缺血脑组织神经元iNOS的表达。
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| 关 键 词： | 复方三酮脑通片 缺血性脑病 大鼠 神经元 |
| 文章编号： | 1001-4454(2006)12-1329-04 |
| 收稿时间： | 2006-02-13 |
| 修稿时间： | 2006年2月13日 |
The Influence of Brain Tectology for MCAO Rats with Compound Santong naotong Pian |
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| LI Gui-hai,SUN Fu-jun,WANG Shi-jun.The Influence of Brain Tectology for MCAO Rats with Compound Santong naotong Pian[J].Jorunal of Chinese Medicinal Materials,2006,29(12):1329-1332. |
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| Authors: | LI Gui-hai SUN Fu-jun WANG Shi-jun |
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| Institution: | 1. Shandong Academy of Chinese Medicine, jinan 250014, China; 2. Shandong University of TCM, Jinan 250014, China |
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| Abstract: | Objective:To observe the influence of on compound santong naotong pian the MCAO rat's brain tectology,and then discuss the gist of medicine effect with the Ischemic Encephalopathy.Methods: The model of MCAO rat was constructed with method of lineuas.The inflect for rat's brain tectology were observed by HE,and the expression of iNOS abducted by brain blood vessel endodermis cell and nerve cell were examied by immunity technique.Results: Compound santong naotong pian could reduce the nerve cell's death rate of CA1 and iNOS abduction, advancd part tiny vassal duild and the renew brain function of MCAO rat.conclusions: Compound santong naotong pian can reduce the nerve cell's death rate of CA1 improve part tiny vassal duild,improve the tiny-Cyc of brain and reduce the iNOS expression. |
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| Keywords: | iNOS |
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