| 淋病球菌单克隆抗体的制备和特性的研究 |
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| 引用本文： | 端青,赵忠利,张国珍,黄策. 淋病球菌单克隆抗体的制备和特性的研究[J]. 细胞与分子免疫学杂志, 1994, 0(2) |
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| 作者姓名： | 端青 赵忠利 张国珍 黄策 |
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| 作者单位： | 军事医学科学院微生物流行病研究所 |
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| 摘 要： | 应用杂交瘤技术筛选出２株淋球菌特异性单克隆抗体Ｎｇ４（ＩｇＧ２ａ）和Ｎｇ１８（ＩｇＧ３）有可能用于淋病的实验诊断．２株单抗的腹水效价可达１０７，抗原识别位点为淋球菌外膜蛋白约３５ｋＤ的糖蛋白成分．在免疫荧光实验中，２株单抗可与不同型淋球菌标准株反应，不与有关的细菌和真菌交叉。
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| 关 键 词： | 抗体，单克隆；淋病球菌 |
The Production and Characterization of Monoclonal Antibodies against Lipooligosaccharide of Neisseria gonorrhoeae |
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| Duang Qing,Zhao Zhongli, Zhang Guozhen,Huang Ce. The Production and Characterization of Monoclonal Antibodies against Lipooligosaccharide of Neisseria gonorrhoeae[J]. Chinese journal of cellular and molecular immunology, 1994, 0(2) |
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| Authors: | Duang Qing Zhao Zhongli Zhang Guozhen Huang Ce |
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| Abstract: | Hybrid cells producing monoclonal antibodies against lipooligosaccharide(LOS)of N.gonorrhoeae were obtained.Monoclonal antibodies Ng4(IgG2a)and Ng18 (IgG3),contained high titers (1: 107) in ascitic fluid. reacted in immunofluorescence assays with 6 reference serotyping strains for N. gonorrhoeae No cross reactions were seen with N. meningitidis, N. subflave, N. lactamica, B. catarrhalis,G.vaginalis,Staphylococcus, Enterobacteriaceae, Pseudomonas spp.and Candida spp. |
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| Keywords: | antibody. monoclonal Neisseria gonorrhoeae |
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