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| 促红细胞生成素对大鼠脊髓损伤后神经生长蛋白43和微管相关蛋白-2表达的影响 | |
| 引用本文： | 王宁,徐纪伟,刘红敏,华新宇. 促红细胞生成素对大鼠脊髓损伤后神经生长蛋白43和微管相关蛋白-2表达的影响[J]. 医学研究杂志, 2016, 45(5): 104-107 |
| 作者姓名： | 王宁 徐纪伟 刘红敏 华新宇 |
| 作者单位： | 462002 漯河医学高等专科学校;462002 漯河医学高等专科学校;462002 漯河医学高等专科学校;462002 漯河医学高等专科学校 |
| 基金项目： | 河南省教育厅自然科学基金资助项目(13B310163) |
| 摘 要： | 目的 观察促红细胞生成素(erythropoietin,EPO)对大鼠脊髓损伤(spinal cord injury,SCI)的保护作用及神经细胞神经生长蛋白43(GAP-43)、微管相关蛋白-2(MAP-2)表达的影响。方法 制作SCI模型,分为假手术组、生理盐水组、EPO治疗组。用免疫组织化学染色方法检测神经细胞内GAP-43和MAP-2的表达变化,同时通过BBB运动评分检测动物的运动功能。结果 EPO治疗组较生理盐水组GAP-43和MAP-2表达水平高,EPO治疗组的BBB运动评分明显优于生理盐水组。结论 EPO能够通过增加GAP-43和MAP-2表达,促进神经细胞生长。 |
| 关 键 词： | 促红细胞生成素 脊髓损伤 神经细胞神经生长蛋白43 微管相关蛋白-2 |
| 收稿时间： | 2015-11-05 |
| 修稿时间： | 2015-11-17 |
Effect of Erythropoietin on GAP-43 and MAP-2 Expression After Spinal Cord Injury in Rats |
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| Wang Ning,Xu Jiwei,Liu Hongmin. Effect of Erythropoietin on GAP-43 and MAP-2 Expression After Spinal Cord Injury in Rats[J]. Journal of Medical Research, 2016, 45(5): 104-107 | |
| Authors: | Wang Ning Xu Jiwei Liu Hongmin |
| Affiliation: | Luohe Medical College, Henan 462002, China;Luohe Medical College, Henan 462002, China;Luohe Medical College, Henan 462002, China;Luohe Medical College, Henan 462002, China |
| Abstract: | Objective To investigate the effect of Erythropoietin on GAP-43 and MAP-2 expression after spinal cord injury in rats. Methods Rats were randomly divided into sham group, NS group and erythropoietin treated group. Immunohistochemistry staining was used to observe GAP-43 and MAP-2 expression. BBB test were used to observe motor function in rats. Results Curcumin treatment group compared with NS group, GAP-43 and MAP-2 expression were significantly increased. The score of BBB test Erythropoietin treatment group were significantly better than NS group. Conclusion Erythropoietin might promote neurons growth by GAP-43 and MAP-2. |
| Keywords: | Erythropoietin Spinal cord iniury GAP-43 MAP-2 |
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