Ⅰ型细胞间粘附分子与肝癌侵袭转移的关系

目的：研究肝癌组织中细胞间粘附分子-1（ICAM-1）的表达与肝癌侵袭转移的关系。方法：应用流式细胞仪检测技术检测了27例人肝癌组织中I型细胞间粘附分子-1的表达,并与正常肝细胞中细胞间粘附分子-1的表达比较,进一步探讨肝癌细胞产生的I型细胞间粘附分子在肝细胞癌侵袭和转移过程中的作用。结果：27例肝癌组织中有24例ICAM-1表达明显增强,其含量明显高于正常组织（P＜0.01),与肿瘤大小、包膜的完整成正相关（P＜0.01),有转移组肝癌组织中ICAM-1的表达明显高于无转移组。结论：ICAM-1与肝癌的侵袭和转移有关,有可能作为预测肝癌转移、复发及预后的指标。

RELATIONSHIP BETWEEN ICAM-1 AND INVASION AND METASTASIS OF HEPATOCELLULAR CARCINOMA

Objective To study the relationship between the intercellular adhesion molecule-1 (ICAM 1) expression of hepatocellular carcinoma (HCC) tissues and its invasion and metastasis.Methods 27 cases of HCC were tested by flow cytometer to investigate the expression of ICAM 1 and compared that with healthy liver tissues.Further searching the function of ICAM 1 in the invasion and metastasis of HCC.Results 24 cases expressed higher level of ICAM 1 than that in healthy liver tissues (P<0.01).The expression of ICAM 1 correlated with the size of tumor and the integration of tumors coat (P<0.01).The expression of ICAM 1 in invasive HCC tissues was higher than that of noninvasive HCC.Conclusion ICAM 1 correlates with the invasion and metastasis of HCC,and may acts as the scale of predict HCC metastasis.recurrence and result.