| 乳腺浸润性导管癌中pS2基因表达的意义 |
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| 引用本文： | 肖虹,梁建芳,张民,杨琴,马艳波,白淘,郑绘霞. 乳腺浸润性导管癌中pS2基因表达的意义[J]. 山西医科大学学报, 2002, 33(2): 104-105 |
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| 作者姓名： | 肖虹 梁建芳 张民 杨琴 马艳波 白淘 郑绘霞 |
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| 作者单位： | 1. 山西医科大学第一临床医学院病理科,太原,030001
2. 山西医科大学第一临床医学院普外科 |
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| 基金项目： | 山西省自然科学基金资助项目 ( 0 12 0 40 ) |
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| 摘 要： | 目的 研究pS2在乳腺浸润性导管癌中的表达与ER、PR及临床指标的关系。方法 应用免疫组化SP法检测 2 40例乳腺癌患者中 pS2的表达。 结果 pS2与雌孕激素受体呈明显的正相关关系 (P <0 0 5 ) ,与乳腺癌分化程度正相关 ,pS2与淋巴结转移情况呈负相关 (P <0 0 5 ) ,与患者年龄、肿瘤大小无明显关系 (P >0 0 5 )。结论 pS2的表达可以作为乳腺癌预后及术后预测抗雌激素治疗效果的重要指标。
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| 关 键 词： | 乳腺浸润性导管癌 pS2 基因表达 乳腺肿瘤 |
| 文章编号： | 1007-6611(2002)02-0103-02 |
| 修稿时间： | 2002-01-21 |
pS2 protein expression in breast cancer and its significance |
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| XIAO Hong,LIANG Jian-fang,ZHANG Min,et al. pS2 protein expression in breast cancer and its significance[J]. Journal of Shanxi Medical University, 2002, 33(2): 104-105 |
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| Authors: | XIAO Hong LIANG Jian-fang ZHANG Min et al |
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| Abstract: | Objective To study the expression of pS2 protein in breast cancer and its relation to ER and PR. Methods Using SP immunohistochemical techhnique, expression of pS2 was studied in 240 patients with breast cancer. Results pS2 expression was positively related to ER and PR (P<0.05),also positively related to the degree of differentiation of breast cancer cells, and negatively related to lymphnode matastasis. The expression of pS2 in breast carcinoma was not related with patient age and tumor size. Conclusion pS2 appears to be a biological marker for predicting prognosis and comprehensive treatment of breast cancer. |
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| Keywords: | breast neoplasms membrane proteins receptors estrogen receptors progesterone |
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