流行性乙型脑炎减毒活疫苗加强免疫的Meta分析

目的 系统评价乙脑减毒活疫苗加强免疫效果并探讨其必要性。方法 计算机检索中国知网、万方数据知识服务平台、Cochrane Database 、PubMed、Web of Science数据库，收集乙脑减毒活疫苗加强免疫的研究，检索时限均为从建库至2015年3月。由2名研究者按照纳入与排除标准筛选文献、提取资料和评价纳入研究的方法学质量，使用Stata 12.0 软件进行统计计算。结果 总共纳入9篇文献。Meta分析结果显示:基础免疫后一个月合并阳性率为79%（95% CI:69%～90%）,基础免疫一年后，接种者的抗体水平下降（合并阳性率51%，95% CI:17%～86%），加强免疫后抗体水平明显升高（合并阳性率98%，95% CI:97%～99%）。结论 乙脑减毒活疫苗加强免疫能提高人群乙脑抗体阳性率和抗体平均几何滴度，有利于达到对人群长期保护的目的。

Immunization efficacy of Japanese encephalitis live attenuated vaccine booster dose: a Meta-analysis

Objective To systematically review the immunization efficacy of Japanese encephalitis live attenuated vaccine booster dose among children. Methods Databases including China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed, Web of Science, Cochrane Library were searched for studies on Japanese encephalitis live attenuated vaccine booster dose. According to the inclusion and exclusion criteria, individual studies were selected by reviewing literatures. Data were aggregated and methodological quality of primary studies was assessed. Meta-analysis was performed using Stata 12.0. Results Nine studies were included in the final meta-analysis. Results showed that the pooled positive rate was (79%; 95% CI: 69%-90%) after the first vaccination and decreased sharply one year later (51%; 95% CI: 17%-86%)). The pooled positive rate increased significantly after a booster dose (98%; 95% CI: 97%-99%). Conclusions Positive rate and GMT of among intervals between first vaccination, one year after first vaccination and booster dose are statistically significant. A booster dose provides better protection against Japanese encephalitis with a higher serological effect.